1,2-dichloroethylene

DATA ITEMS CITED :

38

MOLECULAR FORMULA :

C2-H2-Cl2

MOLECULAR WEIGHT :

96.94

WISWESSER LINE NOTATION :

G1U1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

770 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Amphibian - frog

DOSE/DURATION :

117 mg/m3/1H

TOXIC EFFECTS :

Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - excitement Lungs, Thorax, or Respiration - respiratory depression

MUTATION DATA

TYPE OF TEST :

DNA damage

TEST SYSTEM :

Human Lymphocyte

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 371,185,1996 *** REVIEWS *** ACGIH TLV-TWA 793 mg/m3 (200 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 200 ppm (790 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,80,1971 OSHA PEL (Gen Indu):8H TWA 200 ppm (790 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 200 ppm (790 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 200 ppm (790 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 200 ppm (790 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 200 ppm (790 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 200 ppm (790 mg/m3) JAN 1993 OEL-BELGIUM:TWA 200 ppm (793 mg/m3) JAN 1993 OEL-DENMARK:TWA 200 ppm (790 mg/m3) JAN 1993 OEL-FINLAND:TWA 200 ppm (790 mg/m3);STEL 250 ppm (990 mg/m3) JAN 1993 OEL-GERMANY:TWA 200 ppm (790 mg/m3) JAN 1993 OEL-HUNGARY:TWA 80 mg/m3;STEL 160 mg/m3 JAN 1993 OEL-JAPAN:TWA 150 ppm (590 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 200 ppm (790 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 200 ppm (790 mg/m3) JAN 1993 OEL-POLAND:TWA 50 mg/m3 JAN 1993 OEL-RUSSIA:TWA 150 ppm JAN 1993 OEL-SWITZERLAND:TWA 200 ppm (790 mg/m3);STEL 400 ppm JAN 1993 OEL-TURKEY:TWA 200 ppm (790 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 200 ppm (790 mg/m3);STEL 250 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 1,2-DICHLOROETHYLENE-air:10H TWA 200 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 03350 No. of Facilities: 896 (estimated) No. of Industries: 5 No. of Occupations: 6 No. of Employees: 4673 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 03350 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 7 No. of Employees: 216 (estimated) No. of Female Employees: 10 (estimated)