Ampicillin
Ampicillin structure
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Common Name | Ampicillin | ||
|---|---|---|---|---|
| CAS Number | 69-53-4 | Molecular Weight | 349.405 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 644.5±65.0 °C at 760 mmHg | |
| Molecular Formula | C16H19N3O4S | Melting Point | 198-200 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 343.6±34.3 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
Use of AmpicillinAmpicillin is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria. |
Summary: Ampicillin (69-53-4), with molecular formula C16H19N3O4S and molecular weight 349.405, is a crystalline solid. Used for treating various bacterial infections such as Enterococcus, Shigella, and others. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | ampicillin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Ampicillin is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria. |
|---|---|
| Related Catalog | |
| In Vitro | Ampicillin inhibits the growth of E. coli of swine origin in a dose-dependent manner. The effective inhibitory concentration of Ampicillin was 2.5 uG/mL[1]. |
| In Vivo | Ampicillin is very effective in alleviating the symptoms of hemorrhagic enteritis in a 11-week old pig[1]. Ampicillin produces maximum concentrations in bile twice as high as in serum. The peak concentration of ampicillin after an oral dose is as twice as high in portal blood as in peripheral blood[2]. Ampicillin provides neuroprotection against ischemia-reperfusion brain injury. Ampicillin reduces the activities of MMPs and increases the expression level of GLT-1. Pretreatment with ampicillin significantly reduces medial hippocampal cell death following global forebrain ischemia[3]. |
| Animal Admin | Mice: Ampicillin is dissolved in normal saline. Male C57BL/6 mice were anesthetized with halothane and subjected to bilateral common carotid artery occlusion for 40 min. Before transient forebrain ischemia, ampicillin (200 mg/kg, intraperitoneally [i.p.]) or penicillin G (6,000 U/kg or 20,000 U/kg, i.p.) was administered daily for 5 days. In the control animals, saline was administered at the same volume and time schedule[3]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 644.5±65.0 °C at 760 mmHg |
| Melting Point | 198-200 °C (dec.)(lit.) |
| Molecular Formula | C16H19N3O4S |
| Molecular Weight | 349.405 |
| Flash Point | 343.6±34.3 °C |
| Exact Mass | 349.109619 |
| PSA | 138.03000 |
| LogP | 1.65 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.724 |
| InChIKey | AVKUERGKIZMTKX-NJBDSQKTSA-N |
| SMILES | CC1(C)SC2C(NC(=O)C(N)c3ccccc3)C(=O)N2C1C(=O)O |
| Stability | Stable, but may be moisture sensitive. Incopmpatible with strong oxidizing agents. |
| Water Solubility | NH4OH 1 M: 50 mg/mL, clear, colorless |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H315-H317-H319-H334-H335 |
| Precautionary Statements | P261-P280-P284-P304 + P340-P305 + P351 + P338-P342 + P311 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R36/37/38;R42/43 |
| Safety Phrases | S22-S26-S36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | XH8425000 |
| Packaging Group | I; II; III |
| HS Code | 2941109200 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 8 | |
|---|---|
| DownStream 8 | |
CAS#:551-16-6
CAS#:700-63-0
CAS#:24461-61-8
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CAS#:37091-66-0
CAS#:875-74-1![4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-,1,3-dihydro-3-oxo-1-isobenzofuranyl ester, (2S,5R,6R) structure](https://image.chemsrc.com/caspic/262/47747-56-8.png)
CAS#:47747-56-8
CAS#:51481-65-3
CAS#:61-33-6
CAS#:1252608-05-1
CAS#:611-73-4This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2941109200 |
|---|
This table lists relevant public references with title, journal and publication metadata for this compound.
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Fine mapping and characterization of the L-polymerase-binding domain of the respiratory syncytial virus phosphoprotein.
J. Virol. 89(8) , 4421-33, (2015) The minimum requirement for an active RNA-dependent RNA polymerase of respiratory syncytial virus (RSV) is a complex made of two viral proteins, the polymerase large protein (L) and the phosphoprotein... |
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BBS4 directly affects proliferation and differentiation of adipocytes.
Cell. Mol. Life Sci. 71(17) , 3381-92, (2014) BBS4 is one of several proteins whose defects cause Bardet-Biedl syndrome (BBS), a multi-systemic disorder, manifesting with marked obesity. BBS4 polymorphisms have been associated with common non-syn... |
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An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence.
Proc. Natl. Acad. Sci. U. S. A. 112(7) , E747-56, (2015) The nucleotide cyclic di-3',5'- adenosine monophosphate (c-di-AMP) was recently identified as an essential and widespread second messenger in bacterial signaling. Among c-di-AMP-producing bacteria, al... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| amfipen |
| qidamp |
| ay-6108 |
| binotal |
| Wymox |
| Unasyn |
| (2S,5R,6R)-6-[(R)-2-Amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| MFCD00072036 |
| p-50 |
| ab-pc |
| EINECS 200-709-7 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the melting point of ampicillin? |
| A: Melting point of ampicillin is 198-200 °C (dec.)(lit.). |
| Q: What is the SMILES notation of ampicillin? |
| A: SMILES notation of ampicillin is CC1(C)SC2C(NC(=O)C(N)c3ccccc3)C(=O)N2C1C(=O)O. |
| Q: What is the molecular weight of ampicillin? |
| A: Molecular weight of ampicillin is 349.405. |
| Q: What is the boiling point of ampicillin? |
| A: Boiling point of ampicillin is 644.5±65.0 °C at 760 mmHg. |
| Q: What is the safety information for ampicillin? |
| A: Safety information for ampicillin: S22-S26-S36/37. |
| Q: What is the CAS number of ampicillin? |
| A: CAS number of ampicillin is 69-53-4. |
| Q: What is the LogP of ampicillin? |
| A: LogP of ampicillin is 1.65. |
| Q: What are the downstream products of ampicillin? |
| A: Related downstream products(CAS) of ampicillin: 37091-66-0;551-16-6;875-74-1;47747-56-8;51481-65-3;61-33-6;1252608-05-1;611-73-4. |
| Q: How is the water solubility of ampicillin? |
| A: Water solubility of ampicillin: NH4OH 1 M: 50 mg/mL, clear, colorless. |
| Q: What are the uses of ampicillin? |
| A: Main uses of ampicillin: Ampicillin is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Henan Tianfu Chemical Co., Ltd. |