Prunetin
Prunetin structure
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Common Name | Prunetin | ||
|---|---|---|---|---|
| CAS Number | 552-59-0 | Molecular Weight | 284.263 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 546.5±50.0 °C at 760 mmHg | |
| Molecular Formula | C16H12O5 | Melting Point | 240-242ºC | |
| MSDS | Chinese USA | Flash Point | 209.7±23.6 °C | |
Use of PrunetinPrunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor[1][2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | prunetin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor[1][2]. |
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| Related Catalog | |
| In Vitro | Prunetin inhibited LPS-induced inflammatory cytokine production and MUC5 AC expression and secretion by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 546.5±50.0 °C at 760 mmHg |
| Melting Point | 240-242ºC |
| Molecular Formula | C16H12O5 |
| Molecular Weight | 284.263 |
| Flash Point | 209.7±23.6 °C |
| Exact Mass | 284.068481 |
| PSA | 79.90000 |
| LogP | 3.53 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.669 |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | DJ3100050 |
| HS Code | 2914509090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 9 | |
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| DownStream 2 | |
CAS#:446-72-0
CAS#:74-88-4
CAS#:69127-80-6
CAS#:89595-66-4
CAS#:1162-82-9
CAS#:69127-79-3
CAS#:855829-21-9
CAS#:56982-36-6
CAS#:108-73-6
CAS#:34086-51-6
CAS#:156-38-7This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2914509090 |
|---|---|
| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Preparation and evaluation of surface-bonded tricationic ionic liquid silica as stationary phases for high-performance liquid chromatography.
J. Chromatogr. A. 1396 , 62-71, (2015) Two tricationic ionic liquids were prepared and then bonded onto the surface of supporting silica materials through "thiol-ene" click chemistry as new stationary phases for high-performance liquid chr... |
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Absorption of red clover isoflavones in human subjects: results from a pilot study.
Br. J. Nutr. 103(11) , 1569-72, (2010) In addition to soya-derived preparations, red clover-based dietary supplements have gained considerable interest as an alternative isoflavone (IF) source. While metabolism and bioavailability of the m... |
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The phytoestrogen prunetin affects body composition and improves fitness and lifespan in male Drosophila melanogaster.
FASEB J. 30 , 948-58, (2016) Dietary isoflavones, a group of secondary plant compounds that exhibit phytoestrogenic properties, are primarily found in soy. Prunetin, a representative isoflavone, was recently found to affect cell ... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Induction of osteogenic activity in human MSC assessed as cell differentiation at 1 u...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3111882
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Name: USP8 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 8
External Id: USP8 FAST DUB HTS Primary
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Name: USP17 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 17 like family member 5
External Id: USP17 FAST DUB HTS Primary
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Name: USP7 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 7
External Id: USP7 FAST DUB HTS Primary
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Name: The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Pre...
Source: 11924
Target: N/A
External Id: CGM data for Cell Systems paper Dec 2015
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Name: Induction of osteogenic activity in human MSC assessed as cell differentiation after ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3111869
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Name: Inhibition of EGFR in human A431 cells
Source: ChEMBL
Target: Epidermal growth factor receptor
External Id: CHEMBL941404
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Name: Screen for inhibitors of RMI FANCM (MM2) intereaction
Source: 11908
Target: N/A
External Id: RMI-FANCM-MM2
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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082
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Name: USP30 deubiquitinase inhibition: Dose-response Confirmation
Source: 24642
Target: ubiquitin specific peptidase 30
External Id: USP30 FAST DUB HTS Confirmation
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one |
| Prunusetin |
| 5,4'-dihydroxy-7-methoxyisoflavone |
| Prunetin |
| 7-methoxy-4',5-dihydroxyisoflavone |
| 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxychromen-4-one |
| 7-O-methyl-genistein |
| 4',5-dihydroxy-7-methoxyisoflavone |
| 4',5-dihydroxy-7-methoxygenistein |
| EINECS 209-018-5 |
| MFCD00016951 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the melting point of prunetin? |
| A: Melting point of prunetin is 240-242ºC. |
| Q: What is the boiling point of prunetin? |
| A: Boiling point of prunetin is 546.5±50.0 °C at 760 mmHg. |
| Q: What is the CAS number of prunetin? |
| A: CAS number of prunetin is 552-59-0. |
| Q: What English synonyms does prunetin have? |
| A: English synonyms of prunetin: 5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one, Prunusetin, 5,4'-dihydroxy-7-methoxyisoflavone, Prunetin, 7-methoxy-4',5-dihydroxyisoflavone, 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxychromen-4-one, 7-O-methyl-genistein, 4',5-dihydroxy-7-methoxyisoflavone, 4',5-dihydroxy-7-methoxygenistein, EINECS 209-018-5, MFCD00016951. |
| Q: What is the molecular weight of prunetin? |
| A: Molecular weight of prunetin is 284.263. |
| Q: What is the English name of prunetin? |
| A: The English name of prunetin is prunetin. |
| Q: What is the LogP of prunetin? |
| A: LogP of prunetin is 3.53. |
| Q: What are the uses of prunetin? |
| A: Main uses of prunetin: Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor[1][2]. |
| Q: What are the upstream materials of prunetin? |
| A: Related upstream materials(CAS) of prunetin: 446-72-0;74-88-4;69127-80-6;89595-66-4;1162-82-9;69127-79-3;855829-21-9;56982-36-6;108-73-6. |
| Q: What is the polar surface area (PSA) of prunetin? |
| A: Polar surface area (PSA) of prunetin is 79.90000. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| naturewill |