Magnesium stearate
Magnesium stearate structure
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Common Name | Magnesium stearate | ||
|---|---|---|---|---|
| CAS Number | 557-04-0 | Molecular Weight | 591.24 | |
| Density | 1.028g/cm3 | Boiling Point | 359.4ºC at 760mmHg | |
| Molecular Formula | C36H70MgO4 | Melting Point | 200 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 162.4ºC | |
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The stress stability of olanzapine: studies of interactions with excipients in solid state pharmaceutical formulations.
Drug Dev. Ind. Pharm. 41(3) , 502-14, (2015) Stress stability testing represents an important part of the drug development process. It is used as an important tool for the identification of degradation products and degradation pathways, as well as for the assessment of changes in physical form of drug m... |
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Antisolvent precipitation of novel xylitol-additive crystals to engineer tablets with improved pharmaceutical performance.
Int. J. Pharm. 477(1-2) , 282-93, (2014) The purpose of this work was to develop stable xylitol particles with modified physical properties, improved compactibility and enhanced pharmaceutical performance without altering polymorphic form of xylitol. Xylitol was crystallized using antisolvent crysta... |
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Adrenaline (epinephrine) microcrystal sublingual tablet formulation: enhanced absorption in a preclinical model.
J. Pharm. Pharmacol. 67(1) , 20-5, (2014) For anaphylaxis treatment in community settings, adrenaline (epinephrine) administration using an auto-injector in the thigh is universally recommended. Despite this, many people at risk of anaphylaxis in community settings do not carry their prescribed auto-... |
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Solid formulations by a nanocrystal approach: critical process parameters regarding scale-ability of nanocrystals for tableting applications.
Int. J. Pharm. 485 , 77-86, (2015) Nanocrystallization is among the foremost drug delivery platform approaches for the commercial development of poorly soluble drugs. There exists an urge to enable a universal shift of the production of the solid nanocrystal formulations from laboratory scale ... |
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Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders.
Eur. J. Pharm. Sci. 78 , 264-72, (2015) This study investigates the effects of a variety of coating materials on the flowability and dissolution of dry-coated cohesive ibuprofen powders, with the ultimate aim to use these in oral dosage forms. A mechanofusion approach was employed to apply a 1% (w/... |
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Controlled release of acidic drugs in compendial and physiological hydrogen carbonate buffer from polymer blend-coated oral solid dosage forms.
Eur. J. Pharm. Sci. 77 , 246-53, (2015) The objective of this study was to investigate the suitability of "Eudragit® RL/Eudragit® L55" (RL/L55) blend coatings for a pH-independent release of acidic drugs. A coating for ketoprofen and naproxen mini tablets was developed showing constant drug release... |
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Investigation of the potential for direct compaction of a fine ibuprofen powder dry-coated with magnesium stearate.
Drug Dev. Ind. Pharm. , (2014) Intensive dry powder coating (mechanofusion) with tablet lubricants has previously been shown to give substantial powder flow improvement. This study explores whether the mechanofusion of magnesium stearate (MgSt), on a fine drug powder can substantially impr... |
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Design, development and in-vitro evaluation of diclofenac taste-masked orodispersible tablet formulations.
Drug Dev. Ind. Pharm. 41 , 540-51, (2015) Fast onset of action is prerequisite for acute pain medication. A palatable orodispersible medicine of diclofenac providing rapid analgesic effect should improve patient compliance and treatment.In the present study, diclofenac taste-masked orodispersible tab... |
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A study of micronized poloxamers as lubricants in direct compression of tablets.
Acta Pol. Pharm. 70(6) , 1087-96, (2013) The study evaluates the micronized poloxamers Lptrol micro127 (poloxamer 407) and Lptrol micro 68 (poloxamer 188) as lubricants in combination with the dry binders microcrystalline cellulose and spray-dried lactose. Magnesium stearate was employed as the comp... |
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Disulfiram-loaded immediate and extended release vaginal tablets for the localised treatment of cervical cancer.
J. Pharm. Pharmacol. 67(2) , 189-98, (2015) To develop and manufacture both immediate and sustained release vaginal tablets containing the anticancer drug disulfiram, which has the potential to be used as a non-invasive treatment for cervical cancer.Disulfiram-loaded vaginal tablets were manufactured a... |