DREADD Agonist 21
Modify Date: 2024-01-06 17:25:54
DREADD Agonist 21 structure
|
Common Name | DREADD Agonist 21 | ||
|---|---|---|---|---|
| CAS Number | 56296-18-5 | Molecular Weight | 278.352 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 470.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C17H18N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 238.1±31.5 °C | |
Use of DREADD Agonist 21DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist(EC50=1.7 nM). |
| Name | 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine |
|---|---|
| Synonym | More Synonyms |
| Description | DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist(EC50=1.7 nM). |
|---|---|
| Related Catalog | |
| Target |
EC50: 1.7 nM (hM3Dq)[1] Ki: 6 nM (H1 histamine receptor), 66 nM (5HT2A serotonin receptor 5HT2A), 170 nM (5HT2C serotonin receptor), 280 nM (α1A adrenergic receptor)[1] |
| In Vitro | DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC50=1.7 nM) and does not activate human M3 receptor (hM3). In addition to being inactive at hM3, DREADD agonist 21, a potent full agonist of hM3Dq (EC50=1.7 nM), is only 3.5-fold selective for hM3Dq over H1, 40-fold selective over 5HT2A, 100-fold selective over 5HT2C, and 165-fold selective over α1A. DREADD agonist 21 shows high binding affinities to 5HT2A and 5HT2C serotonin receptor, α1A adrenergic receptor, and H1 histamine receptor with Ki values of 66, 170, 280, and 6 nM, respectively[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 470.1±55.0 °C at 760 mmHg |
| Molecular Formula | C17H18N4 |
| Molecular Weight | 278.352 |
| Flash Point | 238.1±31.5 °C |
| Exact Mass | 278.153137 |
| LogP | 0.98 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.699 |
| Storage condition | 2-8℃ |
| 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine |
| 5H-Dibenzo[b,e][1,4]diazepine, 11-(1-piperazinyl)- |
| DREADD Agonist 21 |