U-37883A
Modify Date: 2024-04-09 12:40:43
U-37883A structure
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Common Name | U-37883A | ||
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| CAS Number | 57568-80-6 | Molecular Weight | 381.98300 | |
| Density | N/A | Boiling Point | 474.1ºC at 760mmHg | |
| Molecular Formula | C21H36ClN3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 240.5ºC | |
Use of U-37883APNU 37883 hydrochloride (PNU 37883A) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker. PNU 37883 hydrochloride has diuretic effects with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells[1][2]. |
| Name | N-(1-adamantyl)-N'-cyclohexylmorpholine-4-carboximidamide,hydrochloride |
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| Synonym | More Synonyms |
| Description | PNU 37883 hydrochloride (PNU 37883A) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker. PNU 37883 hydrochloride has diuretic effects with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells[1][2]. |
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| Related Catalog | |
| In Vitro | In HEK-293 cells stably expressing Kir6.2/SUR1, Kir6.2/SUR2A, Kir6.2/SUR2B or Kir6.1/SUR2B, PNU-37883A inhibits four types of KATP channels, but to different extents. Inhibition of the putative smooth muscle KATP channel types, Kir6.2/SUR2B (IC50 of 15 μM) and Kir6.1/SUR2B (IC50 of 6 μM). PNU-37883A significantly inhibits currents generated by expressing Kir6.2Δ26 alone, with an IC50 of 5 μM, which was significantly increased to 38 μM when Kir6.2Δ26 is expressed with SUR2B[1]. PNU 37883 (0.1-10 nM) hydrochloride produces a concentration-dependent attenuation of the relaxation of agmatine (100 μM) in phenylephrine- or KCl- precontracted aortic rings. However, treatment with PNU 37883 (10 nM) hydrochloride alone does not modify the vascular tone[3]. |
| References |
| Boiling Point | 474.1ºC at 760mmHg |
|---|---|
| Molecular Formula | C21H36ClN3O |
| Molecular Weight | 381.98300 |
| Flash Point | 240.5ºC |
| Exact Mass | 381.25500 |
| PSA | 36.86000 |
| LogP | 4.69650 |
| Safety Phrases | 22-24/25 |
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| 4-Morpholinecarboximidine-N-1-adamantyl-N'-cyclohexane |