Liquiritigenin

Modify Date: 2024-01-02 09:35:07

Liquiritigenin structure	Common Name	Liquiritigenin
	CAS Number	578-86-9	Molecular Weight	256.253
	Density	1.4±0.1 g/cm3	Boiling Point	529.5±50.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₂O₄	Melting Point	206-208ºC
	MSDS	N/A	Flash Point	206.9±23.6 °C

Use of Liquiritigenin

Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC50 of 36.5 nM for activation of the ERE tk-Luc.

Name	liquiritigenin
Synonym	More Synonyms

Description	Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC50 of 36.5 nM for activation of the ERE tk-Luc.
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer Natural Products >> Flavonoids Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	EC50: 36.5 nM (activation of the ERE tk-Luc)[1]
In Vitro	Liquiritigenin produces a dose-response activation of ERE tk-Luc in the U2OS cells transfected with ERβ, but not ERα. Liquiritigenin produces a dose-dependent activation and a time-dependent increase of the CECR6, NKG2E and NKD with ERβ but not with ERα. The ERβ-selectivity of liquiritigenin is due to the selective recruitment of the coactivator steroid receptor coactivator-2 to target genes. Liquiritigenin exhibits similar binding affinities for ERα and ERβ, and causes the recruitment of SRC-2 to target genes selectively in ERβ cells[1]. Pretreatment of MC3T3-E1 cells with liquiritigenin prevents the MG-induced cell death and production of protein adduct, intracellular reactive oxygen species, mitochondrial superoxide, cardiolipin peroxidation, and TNF-α in osteoblastic MC3T3-E1 cells[2].
In Vivo	In a mouse xenograph model, liquiritigenin does not stimulate uterine size or tumorigenesis of MCF-7 breast cancer cells[1]. Treatment with liquiritigenin significantly reduces the concentrations of pro-inflammatory cytokines including interleukin (IL)-6, IL-1β and tumor necrosis factor (TNF)-α in serum and hippocampus[3].
Kinase Assay	The relative binding affinity of liquiritigenin to pure full-length ERα and ERβ is determined using ERα and ERβ competitor assay kits. Fluorescence polarization of the fluorophore-tagged estrogen bound to ERα and ERβ in the presence of increasing amounts of competitor ligand or extract is determined using the GENios Pro microplate reader with fluorescein excitation (485 nM) and emission (530 nM) filters[1].
Animal Admin	Mice: MCF-7 (250,000) cells are grafted under the kidney capsule of nude mice. Five mice per group are treated with a continuous infusion using osmotic pumps containing vehicle, E2 (0.4 mg) or liquiritigenin (2 mg) that infused 2.5 μL/h for 1 month. After one month of treatment, the tumors and uteri are removed and analyzed[1].
References	[1]. Mersereau JE, et al. Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol Cell Endocrinol. 2008 Feb 13;283(1-2):49-57. [2]. Suh KS, et al. Protective effect of liquiritigenin against methylglyoxal cytotoxicity in osteoblastic MC3T3-E1 cells. Food Funct. 2014 Jul 25;5(7):1432-40. [3]. Tao W, et al. Liquiritigenin reverses depression-like behavior in unpredictable chronic mild stress-induced mice by regulating PI3K/Akt/mTOR mediated BDNF/TrkB pathway. Behav Brain Res. 2016 Jul 15;308:177-86.

Density	1.4±0.1 g/cm3
Boiling Point	529.5±50.0 °C at 760 mmHg
Melting Point	206-208ºC
Molecular Formula	C₁₅H₁₂O₄
Molecular Weight	256.253
Flash Point	206.9±23.6 °C
Exact Mass	256.073547
PSA	66.76000
LogP	2.76
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.662

Hazard Codes	Xi
HS Code	29329990

Precursor 2
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(2S)-7-Hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one

Liquiritigenin

(2S)-7-Hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one

BioBioPha
China
Product Name: Liquiritigenin
Price: ￥Inquiry/20mg
Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Liquiritigenin
Price: ￥578.0/20mg
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Liquiritigenin
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Liquiritigenin
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Purity: 98.0%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: good price Liquiritigenin 578-86-9
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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