Hydrochlorothiazide
Hydrochlorothiazide structure
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Common Name | Hydrochlorothiazide | ||
|---|---|---|---|---|
| CAS Number | 58-93-5 | Molecular Weight | 297.739 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 577.0±60.0 °C at 760 mmHg | |
| Molecular Formula | C7H8ClN3O4S2 | Melting Point | 273 °C | |
| MSDS | Chinese USA | Flash Point | 302.7±32.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of HydrochlorothiazideHydrochlorothiazide is a diuretic drug of the thiazide class. Target: OthersHydrochlorothiazide belongs to thiazide class of diuretics. It reduces blood volume by acting on the kidneys to reduce sodium (Na) reabsorption in the distal convoluted tubule. The major site of action in the nephron appears on an electroneutral Na+-Cl? co-transporter by competing for the chloride site on the transporter. By impairing Na transport in the distal convoluted tubule, hydrochlorothiazide induces a natriuresis and concomitant water loss. Thiazides increase the reabsorption of calcium in this segment in a manner unrelated to sodium transport. Additionally, by other mechanisms, Hydrochlorothiazide is believed to lower peripheral vascular resistance [1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | hydrochlorothiazide |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Hydrochlorothiazide is a diuretic drug of the thiazide class. Target: OthersHydrochlorothiazide belongs to thiazide class of diuretics. It reduces blood volume by acting on the kidneys to reduce sodium (Na) reabsorption in the distal convoluted tubule. The major site of action in the nephron appears on an electroneutral Na+-Cl? co-transporter by competing for the chloride site on the transporter. By impairing Na transport in the distal convoluted tubule, hydrochlorothiazide induces a natriuresis and concomitant water loss. Thiazides increase the reabsorption of calcium in this segment in a manner unrelated to sodium transport. Additionally, by other mechanisms, Hydrochlorothiazide is believed to lower peripheral vascular resistance [1]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 577.0±60.0 °C at 760 mmHg |
| Melting Point | 273 °C |
| Molecular Formula | C7H8ClN3O4S2 |
| Molecular Weight | 297.739 |
| Flash Point | 302.7±32.9 °C |
| Exact Mass | 296.964478 |
| PSA | 135.12000 |
| LogP | -0.07 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.632 |
| InChIKey | JZUFKLXOESDKRF-UHFFFAOYSA-N |
| SMILES | NS(=O)(=O)c1cc2c(cc1Cl)NCNS2(=O)=O |
| Stability | Stable. Incompatible with strong oxidizing agents. |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xi,T,F |
| Risk Phrases | R22 |
| Safety Phrases | S22-S24-S36/37-S45-S33-S16-S7 |
| RIDADR | UN 1230 3/PG 2 |
| RTECS | DK9100000 |
| HS Code | 2935009090 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 7 | |
|---|---|
| DownStream 2 | |
CAS#:121-30-2
CAS#:50-00-0
CAS#:58-94-6
CAS#:88150-42-9
CAS#:137862-53-4
CAS#:1318259-41-4
CAS#:671-89-6This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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cIEF for rapid pKa determination of small molecules: a proof of concept.
Eur. J. Pharm. Sci. 63 , 14-21, (2014) A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) w... |
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Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.
Bioorg. Med. Chem. 19 , 1847-51, (2011) A high activity α-carbonic anhydrase (CA, EC 4.2.1.1) has been purified from various tissues of the Antarctic seal Leptonychotes weddellii. The new enzyme, denominated lwCA, has a catalytic activity f... |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| HCTZ |
| 6-Chloro-3,4-Dihydro-(2H)-1,2,4-Benzothiadiazine-7-Sulfonamide 1,1-Dioxide |
| 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide |
| Hydrochlorothiazide |
| Dichlotride |
| MFCD00051765 |
| Aquazide H |
| HCT |
| Esidrix |
| EINECS 200-403-3 |
| Chlorsulfonamidodihydrobenzothiadiazine dioxide |
| 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide |
| Esidrex |
| HYDRODIURIL |
| ORETIC |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the LogP of hydrochlorothiazide? |
| A: LogP of hydrochlorothiazide is -0.07. |
| Q: What is the melting point of hydrochlorothiazide? |
| A: Melting point of hydrochlorothiazide is 273 °C. |
| Q: What are the upstream materials of hydrochlorothiazide? |
| A: Related upstream materials(CAS) of hydrochlorothiazide: 121-30-2;50-00-0;58-94-6;88150-42-9;137862-53-4;1318259-41-4;671-89-6. |
| Q: What is the English name of hydrochlorothiazide? |
| A: The English name of hydrochlorothiazide is hydrochlorothiazide. |
| Q: What is the SMILES notation of hydrochlorothiazide? |
| A: SMILES notation of hydrochlorothiazide is NS(=O)(=O)c1cc2c(cc1Cl)NCNS2(=O)=O. |
| Q: What is the molecular weight of hydrochlorothiazide? |
| A: Molecular weight of hydrochlorothiazide is 297.739. |
| Q: What is the CAS number of hydrochlorothiazide? |
| A: CAS number of hydrochlorothiazide is 58-93-5. |
| Q: What English synonyms does hydrochlorothiazide have? |
| A: English synonyms of hydrochlorothiazide: HCTZ, 6-Chloro-3,4-Dihydro-(2H)-1,2,4-Benzothiadiazine-7-Sulfonamide 1,1-Dioxide, 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, Hydrochlorothiazide, Dichlotride, MFCD00051765, Aquazide H, HCT, Esidrix, EINECS 200-403-3, Chlorsulfonamidodihydrobenzothiadiazine dioxide, 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide, Esidrex, HYDRODIURIL, ORETIC. |
| Q: What is the safety information for hydrochlorothiazide? |
| A: Safety information for hydrochlorothiazide: S22-S24-S36/37-S45-S33-S16-S7. |
| Q: What is the molecular formula of hydrochlorothiazide? |
| A: Molecular formula of hydrochlorothiazide is C7H8ClN3O4S2. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Henan Tianfu Chemical Co., Ltd. |