2',3'-Dideoxyuridine

Modify Date: 2024-01-08 11:44:11

2',3'-Dideoxyuridine Structure
2',3'-Dideoxyuridine structure
Common Name 2',3'-Dideoxyuridine
CAS Number 5983-09-5 Molecular Weight 212.20
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C9H12N2O4 Melting Point 127-129 °C(lit.)
MSDS Chinese USA Flash Point N/A

 Use of 2',3'-Dideoxyuridine


2',3'-Dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 2',3'-Dideoxyuridine
Synonym More Synonyms

 2',3'-Dideoxyuridine Biological Activity

Description 2',3'-Dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Melting Point 127-129 °C(lit.)
Molecular Formula C9H12N2O4
Molecular Weight 212.20
Exact Mass 226.095352
PSA 84.32000
LogP -0.76
Index of Refraction 1.552
Storage condition 2~8°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes C
Risk Phrases 34-36/37
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2934999090

 Synthetic Route

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles10

More Articles
Abacavir and metabolite pharmacokinetics in HIV-1-infected children and adolescents.

J. Acquir. Immune Defic. Syndr. 51(1) , 54-9, (2009)

Abacavir (ABC) oral clearance, adjusted for body size, is approximately 2 times higher for children than adults with a corresponding difference in dose regimens. However, there are limited data availa...

Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxyuridine-5'-triphosphate.

Mol. Pharmacol. 37(2) , 157-63, (1990)

2',3'-Dideoxyuridine (ddUrd) exhibits poor if any anti-human immunodeficiency virus (HIV) activity in ATH8 and MT-4 cells. This is in agreement with the failure of ddUrd to be efficiently anabolized i...

Glycosyl-oxycarbonylaminosulfonyl-2',3'-dideoxynucleoside derivatives as lipophilic nucleotide mimics. Synthesis and anti-HIV activity.

Bioorg. Med. Chem. 1(4) , 279-84, (1993)

Several lipophilic-2',3'-dideoxynucleotide analogues have been synthesized and tested against Human Immunodeficiency Virus (HIV). Glycosyl-oxycarbonylaminosulfonyl-analogues of 3'-deoxythymidine and 2...

 Synonyms

1-[5-(Hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
1-[5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
1-[(2R,5S)-5-(Hydroxymethyl)tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 1-[(2R,5S)-tetrahydro-5-(hydroxymethyl)-2-furanyl]-
2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-[tetrahydro-5-(hydroxymethyl)-2-furanyl]-
MFCD00013359
1-[(2R,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione
1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
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