2',3'-Dideoxyuridine

Modify Date: 2025-08-20 12:24:48

2',3'-Dideoxyuridine structure	Common Name	2',3'-Dideoxyuridine
	CAS Number	5983-09-5	Molecular Weight	212.20
	Density	1.3±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₉H₁₂N₂O₄	Melting Point	127-129 °C(lit.)
	MSDS	Chinese USA	Flash Point	N/A

Use of 2',3'-Dideoxyuridine

2',3'-Dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	2',3'-Dideoxyuridine
Synonym	More Synonyms

Description	2',3'-Dideoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Density	1.3±0.1 g/cm3
Melting Point	127-129 °C(lit.)
Molecular Formula	C₉H₁₂N₂O₄
Molecular Weight	212.20
Exact Mass	226.095352
PSA	84.32000
LogP	-0.76
Index of Refraction	1.552
Storage condition	2~8°C

2',3'-Dideoxyuridine MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	C
Risk Phrases	34-36/37
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2934999090

Precursor 6
CAS#:5974-93-6 2',3'-Didehydro... CAS#:951-78-0 2'-deoxyuridine CAS#:58-96-8 Uridine CAS#:7481-89-2 Zalcitabine
CAS#:42867-74-3 5’-O-Acetyl-2’,... CAS#:16628-81-2 2',3'-O-(Methox...
DownStream 10
CAS#:107550-74-3 [(2S,5R)-5-(2-a... CAS#:4097-22-7 2',3'-Dideoxyad... CAS#:7481-89-2 Zalcitabine CAS#:69655-05-6 2',3'-Dideoxyinosine
CAS#:66-22-8 Uracil CAS#:132194-24-2 (2S)-5α-(6-Fluo... CAS#:132194-27-5 [(2S,5R)-5-(2,6... CAS#:132194-25-3 (2S)-5α-(6-Brom...
CAS#:105784-83-6 2',3'-Dideoxy-5... CAS#:126502-08-7 [(2S,5R)-5-puri...

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Abacavir and metabolite pharmacokinetics in HIV-1-infected children and adolescents.

J. Acquir. Immune Defic. Syndr. 51(1) , 54-9, (2009)

Abacavir (ABC) oral clearance, adjusted for body size, is approximately 2 times higher for children than adults with a corresponding difference in dose regimens. However, there are limited data availa...

Potent DNA chain termination activity and selective inhibition of human immunodeficiency virus reverse transcriptase by 2',3'-dideoxyuridine-5'-triphosphate.

Mol. Pharmacol. 37(2) , 157-63, (1990)

2',3'-Dideoxyuridine (ddUrd) exhibits poor if any anti-human immunodeficiency virus (HIV) activity in ATH8 and MT-4 cells. This is in agreement with the failure of ddUrd to be efficiently anabolized i...

Glycosyl-oxycarbonylaminosulfonyl-2',3'-dideoxynucleoside derivatives as lipophilic nucleotide mimics. Synthesis and anti-HIV activity.

Bioorg. Med. Chem. 1(4) , 279-84, (1993)

Several lipophilic-2',3'-dideoxynucleotide analogues have been synthesized and tested against Human Immunodeficiency Virus (HIV). Glycosyl-oxycarbonylaminosulfonyl-analogues of 3'-deoxythymidine and 2...

1-[5-(Hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

1-[5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione

1-[(2R,5S)-5-(Hydroxymethyl)tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione

2,4(1H,3H)-Pyrimidinedione, 1-[(2R,5S)-tetrahydro-5-(hydroxymethyl)-2-furanyl]-

2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-[tetrahydro-5-(hydroxymethyl)-2-furanyl]-

MFCD00013359

1-[(2R,5S)-5-(Hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione

1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

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2',3'-Dideoxyuridine

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