L-Dihydroorotic acid

Modify Date: 2024-01-02 18:15:58

L-Dihydroorotic acid Structure
L-Dihydroorotic acid structure
 Common Name L-Dihydroorotic acid
CAS Number 5988-19-2 Molecular Weight 158.112
Density 1.9±0.1 g/cm3 Boiling Point 524.0±60.0 °C at 760 mmHg
Molecular Formula C5H6N2O4 Melting Point 254-255 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 270.7±32.9 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of L-Dihydroorotic acid


L-Dihydroorotic acid can reversibly hydrolyze to yield the acyclic L-ureidosuccinic acid by dihydrowhey enzyme[1].

 Names

Name (S)-dihydroorotic acid
Synonym More Synonyms

 L-Dihydroorotic acid Biological Activity

Description L-Dihydroorotic acid can reversibly hydrolyze to yield the acyclic L-ureidosuccinic acid by dihydrowhey enzyme[1].
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. St. Louis, Missouri,et al. ENZYMATIC SYNTHESIS AND BREAKDOWN OF A PYRIMIDINE, OROTIC ACID.October 28, 1953.

 Chemical & Physical Properties

Density 1.9±0.1 g/cm3
Boiling Point 524.0±60.0 °C at 760 mmHg
Melting Point 254-255 °C (dec.)(lit.)
Molecular Formula C5H6N2O4
Molecular Weight 158.112
Flash Point 270.7±32.9 °C
Exact Mass 158.032761
PSA 95.50000
LogP -2.29
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.714
Storage condition Store at 0-5°C

 MSDS

Material Safety Data Sheet
Section1. Identification of the substance
L-Dihydroorotic acid
Product Name:
Synonyms:
Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H315:Causes skin irritation
H319:Causes serious eye irritation
H335:May cause respiratory irritation
P261:Avoid breathing dust/fume/gas/mist/vapours/spray
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P302+P352:IF ON SKIN: Wash with soap and water
P321:Specific treatment (see on this label)
P405:Store locked up
Section3. Composition/information on ingredients.
L-Dihydroorotic acid
Ingredient name:
CAS number:5988-19-2
Section4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Ingestion:
Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.
Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.
Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels.
Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.
Section9. Physical and chemical properties
Not specified
Appearance:
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula:C5H6N2O4
Molecular weight:158.1
Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.
Section11. Toxicological information
No data.
Section12. Ecological information
No data.
Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.
Section14. Transportation information
Non-harzardous for air and ground transportation.
Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2934999001

 Customs

HS Code 2934999001

 Articles26

More Articles
SEC-TID: A Label-Free Method for Small-Molecule Target Identification.

J. Biomol. Screen. 19(6) , 917-927, (2014)

Bioactive small molecules are an invaluable source of therapeutics and chemical probes for exploring biological pathways. Yet, significant hurdles in drug discovery often come from lacking a comprehen...

The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites.

Biochemistry 47(34) , 8929-36, (2008)

Inhibitors of dihydroorotate dehydrogenase (DHODH) have been suggested for the treatment of rheumatoid arthritis, psoriasis, autoimmune diseases, Plasmodium, and bacterial and fungal infections. Here ...

Miller (Genee-Wiedemann) syndrome represents a clinically and biochemically distinct subgroup of postaxial acrofacial dysostosis associated with partial deficiency of DHODH.

Hum. Mol. Genet. 21(18) , 3969-83, (2012)

Biallelic mutations in the gene encoding DHOdehase [dihydroorotate dehydrogenase (DHODH)], an enzyme required for de novo pyrimidine biosynthesis, have been identified as the cause of Miller (Genée-We...

 Synonyms

(S)-dihydroorotic acid
dihydroorotate
MFCD00085339
(S)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
(S)-2,6-dioxo-hexahydro-pyrimidine-4-carboxylic acid
4-Pyrimidinecarboxylic acid, 4,5-dihydro-2,6-dihydroxy-, (4S)-
(4S)-2,6-Dioxohexahydropyrimidine-4-carboxylic acid
(4S)-2,6-Dihydroxy-4,5-dihydro-4-pyrimidinecarboxylic acid
L-Dihydroorotic Acid
(4S)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
EINECS 204-352-8
4-Pyrimidinecarboxylic acid, hexahydro-2,6-dioxo-, (4S)-
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