Linoleic acid

Modify Date: 2024-01-01 21:56:37

Linoleic acid Structure
Linoleic acid structure
Common Name Linoleic acid
CAS Number 60-33-3 Molecular Weight 280.445
Density 0.9±0.1 g/cm3 Boiling Point 360.6±0.0 °C at 760 mmHg
Molecular Formula C18H32O2 Melting Point -5 °C
MSDS Chinese USA Flash Point 273.0±14.4 °C

 Use of Linoleic acid


Linoleic acid is a critical component of polyunsaturated fatty acids.

 Names

Name linoleic acid
Synonym More Synonyms

 Linoleic acid Biological Activity

Description Linoleic acid is a critical component of polyunsaturated fatty acids.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Linoleic acid contains unsaturated double bonds that are highly vulnerable to free radical attack and oxidation. If ROS are produced in great quantities, the body can no longer efficiently remove them. In such instances, ROS may be released into the extracellular space, causing damage to surrounding cells and tissues. Linoleic acid is a decomposition product of a free fatty acid and has been linked to erythrocyte damage[1].
References

[1]. Yuan T, et al. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism. Int J Clin Exp Pathol. 2015 May 1;8(5):5044-52.

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 360.6±0.0 °C at 760 mmHg
Melting Point -5 °C
Molecular Formula C18H32O2
Molecular Weight 280.445
Flash Point 273.0±14.4 °C
Exact Mass 280.240234
PSA 37.30000
LogP 7.18
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.478
Storage condition 2-8°C
Stability Stability Stable, but air and light sensitive. Combustible. Incompatible with strong oxidizing agents.
Water Solubility INSOLUBLE
Freezing Point -5℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RF9990000
CHEMICAL NAME :
9,12-Octadecadienoic acid, (Z)-
CAS REGISTRY NUMBER :
60-33-3
LAST UPDATED :
199710
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C18-H32-O2
MOLECULAR WEIGHT :
280.50
WISWESSER LINE NOTATION :
QV8U3U6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Human
REFERENCE :
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>50 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,327,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>50 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3728459
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
280 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 104,793,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 43040 No. of Facilities: 4852 (estimated) No. of Industries: 61 No. of Occupations: 64 No. of Employees: 45762 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 43040 No. of Facilities: 2186 (estimated) No. of Industries: 26 No. of Occupations: 37 No. of Employees: 57612 (estimated) No. of Female Employees: 16829 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
Hazard Codes Xi
Risk Phrases R36
Safety Phrases S26-S24/25-S36
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS RF9990000
HS Code 2916150000

 Synthetic Route

 Customs

HS Code 2916190090
Summary 2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

 Articles344

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 Synonyms

MFCD00064241
cis,cis-9,12-octadecadienoic acid
Pamolyn
9,12-Octadecadienoic acid, (9Z,12Z)-
FEMA 3380
Hidiene
cis-9,cis-12-octadecadienoic acid
Linoleic acid
LINOLEATE
emersol310
unifac6550
EINECS 200-470-9
9-cis,12-cis-Octadecadienoic acid
IVELIP
(9Z,12Z)-9,12-Octadecadienoic acid
cis-Linoleic acid
emersol315
Linoleic
9,12-octadecadienoic acid
(9Z,12Z)-octadeca-9,12-dienoic acid
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