Cholest-4-en-3-one

Modify Date: 2024-01-03 18:27:37

Cholest-4-en-3-one structure	Common Name	Cholest-4-en-3-one
	CAS Number	601-57-0	Molecular Weight	384.638
	Density	1.0±0.1 g/cm3	Boiling Point	482.7±12.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₄₄O	Melting Point	79-82 °C
	MSDS	N/A	Flash Point	247.7±10.4 °C

Use of Cholest-4-en-3-one

Cholestenone is the intermediate oxidation product of cholesterol.

Name	cholest-4-en-3-one
Synonym	More Synonyms

Description	Cholestenone is the intermediate oxidation product of cholesterol.
Related Catalog	Natural Products >> Others Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
References	[1]. Rosenheim O, et al. The mechanism of coprosterol formation in vivo: 1. Cholestenone as an intermediate. Biochem J. 1943 Oct;37(4):513-4.

Density	1.0±0.1 g/cm3
Boiling Point	482.7±12.0 °C at 760 mmHg
Melting Point	79-82 °C
Molecular Formula	C₂₇H₄₄O
Molecular Weight	384.638
Flash Point	247.7±10.4 °C
Exact Mass	384.339203
PSA	17.07000
LogP	9.36
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.519

Name:	4-Cholesten-3-one 99.5+%(tlc) Material Safety Data Sheet
Synonym:	3-Oxo-4-cholesten
CAS:	601-57-0

Section 1 - Chemical Product MSDS Name:4-Cholesten-3-one 99.5+%(tlc) Material Safety Data Sheet
Synonym:3-Oxo-4-cholesten

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
601-57-0	4-CHOLESTEN-3-ONE	99.5+%	210-005-1

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 601-57-0: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: very slightly yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 79 - 81 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C27H44O
Molecular Weight: 384.64

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 601-57-0: FZ7700000 LD50/LC50:
Not available.
Carcinogenicity:
4-CHOLESTEN-3-ONE - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 601-57-0: No information available.
Canada
CAS# 601-57-0 is listed on Canada's NDSL List.
CAS# 601-57-0 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 601-57-0 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FZ7700000

CHEMICAL NAME :: Cholest-4-en-3-one

CAS REGISTRY NUMBER :: 601-57-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C27-H44-O

MOLECULAR WEIGHT :: 384.71

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 94 mg/kg

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl 6),41,1986

Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	S22-S24/25
WGK Germany	3
RTECS	FZ7700000
HS Code	29142900

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