Lodoxamide tromethamine

Modify Date: 2024-01-05 09:59:42

Lodoxamide tromethamine structure	Common Name	Lodoxamide tromethamine
	CAS Number	63610-09-3	Molecular Weight	553.90500
	Density	N/A	Boiling Point	827.5ºC at 760 mmHg
	Molecular Formula	C₁₉H₂₈ClN₅O₁₂	Melting Point	N/A
	MSDS	N/A	Flash Point	454.3ºC

Use of Lodoxamide tromethamine

Lodoxamide tromethamine (U 42585 E) is a medication for the treatment of prophylaxis of mast cell-mediated allergic disease.

Name	Lodoxamidetromethamine
Synonym	More Synonyms

Description	Lodoxamide tromethamine (U 42585 E) is a medication for the treatment of prophylaxis of mast cell-mediated allergic disease.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology
In Vitro	lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced 45Ca influx with associated histamine release in purified rat peritoneal mast cells[1].
In Vivo	Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model3 and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anesthetized rhesus monkeys[1]. Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation, decreased microvascular permeability, and increased compliance[2]. Patients treated with lodoxamide tromethamine demonstrate an improvement in daytime breathing difficulty, cough, sputum production, and sleep[3].
References	[1]. Watt GD, et al. Protective effect opf lodoxamide tromethamine on allergen inhalation challenge. J Allergy Clin Immunol. 1980 Oct;66(4):286-94. [2]. Barr ML, et al. Addition of a mast cell stabilizing compound to organ preservation solutions decreases lung reperfusion injury. J Thorac Cardiovasc Surg. 1998 Mar;115(3):631-6; discussion 636-7. [3]. Mann JS, et al. Inhaled lodoxamide tromethamine in the treatment of perennial asthma: a double-blind placebo-controlled study. J Allergy Clin Immunol. 1985 Jul;76(1):83-90.

Boiling Point	827.5ºC at 760 mmHg
Molecular Formula	C₁₉H₂₈ClN₅O₁₂
Molecular Weight	553.90500
Flash Point	454.3ºC
Exact Mass	553.14200
PSA	330.01000
Storage condition	-20℃

Hazard Codes	N

LodoxaMide troMethaMineon

Lodoxamide (tromethamine)

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China
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China
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China
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China
Product Name: Lodoxamide tromethamine
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Lodoxamidetromethamine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
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Price: ￥561.6/25mg

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