LY 117018

Modify Date: 2024-01-24 12:17:23

LY 117018 structure	Common Name	LY 117018
	CAS Number	63676-25-5	Molecular Weight	459.55700
	Density	1.314g/cm3	Boiling Point	721.5ºC at 760 mmHg
	Molecular Formula	C₂₇H₂₅NO₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	390.2ºC

Use of LY 117018

LY117018, a Raloxifene analog, is a selective estrogen receptor modulator. LY117018 exerts antiproliferative effects on breast cancer cell lines[1][2].

Name	Phenethipylone
Synonym	More Synonyms

Description	LY117018, a Raloxifene analog, is a selective estrogen receptor modulator. LY117018 exerts antiproliferative effects on breast cancer cell lines[1][2].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer
Target	Estrogen receptor
In Vitro	LY117018 (0.01-1000 nM; 24 hours) at lower concentrations (0.01-10 nM) caused an E2-like increase in p53 levels when compared to its effects on cells grown in the stripped medium. At a higher concentration of LY117018 (1 μM), the level of p53 appeared to decline. Treatment with 1 μM LY117018 resulted in a predominantly hypophosphorylated pRb. At lower concentrations, LY117018 did not block E2-induced pRb phosphorylation[1]. LY117018 (1 μM; 96 hours) inhibits MCF-7 cells proliferation with an IC50 of 1 μM[2]. LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway[3]. Cell Proliferation Assay[2] Cell Line: MCF-7 cells Concentration: 1 μM Incubation Time: 96 hours Result: Inhibited MCF-7 cells proliferation with an IC50 of 1 μM.
References	[1]. Dinda S, et al. Effects of LY117018 (a SERM analog of raloxifene) on tumor suppressor proteins and proliferation of breast cancer cells.Horm Mol Biol Clin Investig. 2010 Aug 1;2(1):211-7. [2]. Baumann KH, et al. Effects of celecoxib and ly117018 combination on human breast cancer cells in vitro.Breast Cancer (Auckl). 2009 Apr 7;3:23-34. [3]. Yu J, et al.Raloxifene analogue LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway.Eur J Pharmacol. 2008 Jul 28;589(1-3):32-6.

Density	1.314g/cm3
Boiling Point	721.5ºC at 760 mmHg
Molecular Formula	C₂₇H₂₅NO₄S
Molecular Weight	459.55700
Flash Point	390.2ºC
Exact Mass	459.15000
PSA	98.24000
LogP	5.62300
Index of Refraction	1.679

Precursor 10
CAS#:84449-67-2 [6-acetoxy-2-(4... CAS#:84449-70-7 6-methanesulfon... CAS#:84449-69-4 [6-(benzoyloxy)... CAS#:15570-12-4 4-Methoxythiophenol
CAS#:63675-74-1 6-Methoxy-2-(4-... CAS#:63676-22-2 Estrogen recept... CAS#:63675-91-2 4-[2-(1-pyrroli... CAS#:63675-73-0 4-Methoxy-alpha...
CAS#:63675-90-1 4-(2-pyrrolidin... CAS#:2632-13-5 PTP inhibitor 1
DownStream 0

Methanone,(6-hydroxy-2-(4-hydroxyphenyl)benzo(B)thien-3-yl)(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)

[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-pyrrolidinyl)ethoxy]phenyl]methanone

6-Hydroxy-2-(4-hydroxyphenyl)benzo(B)thien-3-yl 4-(2-(1-pyrrolidinyl)ethoxy) phenyl ketone

DC Chemicals Limited
China
Product Name: LY117018
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Phenethipylone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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