Boc-6-aminohexanoic acid

Modify Date: 2024-01-02 13:35:34

Boc-6-aminohexanoic acid Structure
Boc-6-aminohexanoic acid structure
Common Name Boc-6-aminohexanoic acid
CAS Number 6404-29-1 Molecular Weight 231.289
Density 1.1±0.1 g/cm3 Boiling Point 380.3±25.0 °C at 760 mmHg
Molecular Formula C11H21NO4 Melting Point 35-40 °C
MSDS USA Flash Point 183.8±23.2 °C

 Use of Boc-6-aminohexanoic acid


Boc-6-aminohexanoic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Boc-6-aminohexanoic acid
Synonym More Synonyms

 Boc-6-aminohexanoic acid Biological Activity

Description Boc-6-aminohexanoic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 380.3±25.0 °C at 760 mmHg
Melting Point 35-40 °C
Molecular Formula C11H21NO4
Molecular Weight 231.289
Flash Point 183.8±23.2 °C
Exact Mass 231.147064
PSA 75.63000
LogP 1.67
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.464
Storage condition 2-8°C

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases S22-S24/25-S26
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2924199090

 Synthetic Route

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles4

More Articles
The literature on affinity chromatography.

Meth. Enzymol. 34 , 3, (1974)

Affinity chromatography of carboxypeptidase B.

Meth. Enzymol. 34 , 411, (1974)

Synthesis and properties of radioiodinated phospholipid analogues that spontaneously undergo vesicle-vesicle and vesicle-cell transfer.

Biochemistry 22 , 3617, (1983)

An efficient method for the synthesis and purification of a variety of iodinated phospholipid analogues is described. 1-Acyl-2-[[[3-(3-[125I]iodo-4-hydroxyphenyl)- propionyl]amino]caproyl]phosphatidyl...

 Synonyms

6-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)hexanoic acid
6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid
6-[(tert-butoxycarbonyl)amino]hexanoic acid
Hexanoic acid, 6-[[(1,1-dimethylethoxy)carbonyl]amino]-
MFCD00037798
Boc-ε-Acp-OH
Boc-ε-Ahx-OH
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