M 30 dihydrochloride

Modify Date: 2024-01-06 22:50:34

M 30 dihydrochloride structure	Common Name	M 30 dihydrochloride
	CAS Number	64821-19-8	Molecular Weight	299.19600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₆Cl₂N₂O	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS05, GHS07	Signal Word	Danger

Use of M 30 dihydrochloride

MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC50=37 nM) and MAO-B (IC50=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease[1][2][3].

Name	5-[[methyl(prop-2-ynyl)amino]methyl]quinolin-8-ol,dihydrochloride
Synonym	More Synonyms

Description	MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC50=37 nM) and MAO-B (IC50=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
Target	MAO-A:37 nM (IC50) MAO-B:57 nM (IC50)
In Vitro	MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone[3]. MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival[4]. MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells[3]. Cell Viability Assay[3] Cell Line: SH-SY5Y cells Concentration: 0.25 nM Incubation Time: 72 hours Result: Significantly increased cell viability to ∼90% after exposure to Dexamethasone. Cell Viability Assay[4] Cell Line: PC12 cells Concentration: 0-10 μM Incubation Time: 24 hours Result: Enhanced the PC12 cell viability, the cell viability increasing to 85 ± 6 and 90 ± 7%.
In Vivo	MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities[6]. Animal Model: Male C57/BL mice (20-22 g; MPTP-induced neurotoxicity in mice)[6] Dosage: 0.5, 2.5 mg/kg Administration: P.o.; once daily for 14 consecutive days Result: Significantly elevate striatal dopamine levels, reduce its metabolism, and elevate tyrosine-hydroxylase protein levels and activity. Elevated MPTP-reduced dopaminergic and transferrin receptor cell count in the SNpc.
References	[1]. Gal S, et al. M30, a novel multifunctional neuroprotective drug with potent iron chelating and brain selective monoamine oxidase-ab inhibitory activity for Parkinson's disease. J Neural Transm Suppl. 2006;(70):447-456. [2]. Zheng H, et al. Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition. J Neurochem. 2005;95(1):68-78. [3]. Gal S, et al. Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal dopamine depletion. J Neurochem. 2005;95(1):79-88. [4]. Gal S, et al. Restoration of nigrostriatal dopamine neurons in post-MPTP treatment by the novel multifunctional brain-permeable iron chelator-monoamine oxidase inhibitor drug, M30. Neurotox Res. 2010;17(1):15-27.

Molecular Formula	C₁₄H₁₆Cl₂N₂O
Molecular Weight	299.19600
Exact Mass	298.06400
PSA	36.36000
LogP	3.60940

M 30 dihydrochloride MSDS(Chinese)

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H318
Precautionary Statements	P280-P305 + P351 + P338
RIDADR	NONH for all modes of transport

M30 dihydrochloride

DC Chemicals Limited
China
Product Name: MAO-IN-M30 dihydrochloride
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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