![]() 4,8-Dimethoxy-1-vinyl-9H-β-carboline structure
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Common Name | 4,8-Dimethoxy-1-vinyl-9H-β-carboline | ||
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CAS Number | 65236-62-6 | Molecular Weight | 254.284 | |
Density | 1.3±0.1 g/cm3 | Boiling Point | 491.8±40.0 °C at 760 mmHg | |
Molecular Formula | C15H14N2O2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 174.9±17.6 °C |
Use of 4,8-Dimethoxy-1-vinyl-9H-β-carbolineDehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[1][2]. |
Name | 1-ethenyl-4,8-dimethoxy-9H-pyrido[3,4-b]indole |
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Synonym | More Synonyms |
Description | Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[1][2]. |
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Related Catalog | |
In Vitro | Dehydrocrenatidine inhibits JAK-STAT3 dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine inhibits JAKs-JH1 domain over-expression induced STAT3 and STAT1 phosphorylations[1]. Dehydrocrenatidine diminishes IL-6, IFNα and IFNγ stimulated STAT3 phosphorylation as well as constitutive STAT3 phosphorylation[1]. DHCT suppresses both tetrodotoxin-resistant (TTX-R) and sensitive (TTX-S) voltage-gated sodium channel (VGSC) currents with IC50 values of 12.36 µM and 4.87 µM, respectively[2]. |
In Vivo | Dehydrocrenatidine inhibits JAK-STAT3 dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine inhibits JAKs-JH1 domain over-expression induced STAT3 and STAT1 phosphorylations[1]. Dehydrocrenatidine diminishes IL-6, IFNα and IFNγ stimulated STAT3 phosphorylation as well as constitutive STAT3 phosphorylation[1]. DHCT suppresses both tetrodotoxin-resistant (TTX-R) and sensitive (TTX-S) voltage-gated sodium channel (VGSC) currents with IC50 values of 12.36 µM and 4.87 µM, respectively[2]. |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 491.8±40.0 °C at 760 mmHg |
Molecular Formula | C15H14N2O2 |
Molecular Weight | 254.284 |
Flash Point | 174.9±17.6 °C |
Exact Mass | 254.105530 |
PSA | 47.14000 |
LogP | 3.70 |
Vapour Pressure | 0.0±1.2 mmHg at 25°C |
Index of Refraction | 1.703 |
Hazard Codes | Xi |
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~% 4,8-Dimethoxy-1... CAS#:65236-62-6 |
Literature: Ohmoto; Koike; Higuchi; Ikeda Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 8 p. 3356 - 3360 |
Precursor 2 | |
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DownStream 0 |
9H-Pyrido[3,4-b]indole, 1-ethenyl-4,8-dimethoxy- |
4,8-Dimethoxy-1-vinyl-9H-β-carboline |
8-O-methylpicrasidine I |
1-ethenyl-4,8-dimethoxy-9H-β-carboline |
Dehydrocrenatidin |