Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4,8-Dimethoxy-1-vinyl-9H-β-carboline
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Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4,8-Dimethoxy-1-vinyl-9H-β-carboline
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Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Dehydrocrenatidine
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: DEHYDROCRENATIDINE
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Purity: 98.0%
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65236-62-6

65236-62-6 structure

Name: 4,8-Dimethoxy-1-vinyl-9H-β-carboline
Chemical Name: 1-ethenyl-4,8-dimethoxy-9H-pyrido[3,4-b]indole
CAS Number: 65236-62-6
Molecular Formula: C₁₅H₁₄N₂O₂
Molecular Weight: 254.284
Catalog: Natural product Alkaloid
Create Date: 2017-06-17 05:27:50
Modify Date: 2024-01-08 16:40:20
Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[1][2].

Name	1-ethenyl-4,8-dimethoxy-9H-pyrido[3,4-b]indole
Synonyms	9H-Pyrido[3,4-b]indole, 1-ethenyl-4,8-dimethoxy- 4,8-Dimethoxy-1-vinyl-9H-β-carboline 8-O-methylpicrasidine I 1-ethenyl-4,8-dimethoxy-9H-β-carboline Dehydrocrenatidin

Description	Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Neurological Disease
In Vitro	Dehydrocrenatidine inhibits JAK-STAT3 dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine inhibits JAKs-JH1 domain over-expression induced STAT3 and STAT1 phosphorylations[1]. Dehydrocrenatidine diminishes IL-6, IFNα and IFNγ stimulated STAT3 phosphorylation as well as constitutive STAT3 phosphorylation[1]. DHCT suppresses both tetrodotoxin-resistant (TTX-R) and sensitive (TTX-S) voltage-gated sodium channel (VGSC) currents with IC50 values of 12.36 µM and 4.87 µM, respectively[2].
In Vivo	Dehydrocrenatidine inhibits JAK-STAT3 dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine inhibits JAKs-JH1 domain over-expression induced STAT3 and STAT1 phosphorylations[1]. Dehydrocrenatidine diminishes IL-6, IFNα and IFNγ stimulated STAT3 phosphorylation as well as constitutive STAT3 phosphorylation[1]. DHCT suppresses both tetrodotoxin-resistant (TTX-R) and sensitive (TTX-S) voltage-gated sodium channel (VGSC) currents with IC50 values of 12.36 µM and 4.87 µM, respectively[2].
References	[1]. Jing Zhang, et al. Dehydrocrenatidine is a novel janus kinase inhibitor. Mol Pharmacol. 2015 Apr;87(4):572-81. [2]. Fang Zhao, et al. Dehydrocrenatidine Inhibits Voltage-Gated Sodium Channels and Ameliorates Mechanic Allodia in a Rat Model of Neuropathic Pain. Toxins (Basel). 2019 Apr 18;11(4):229.

Density	1.3±0.1 g/cm3
Boiling Point	491.8±40.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₄N₂O₂
Molecular Weight	254.284
Flash Point	174.9±17.6 °C
Exact Mass	254.105530
PSA	47.14000
LogP	3.70
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.703

Hazard Codes	Xi

186581-53-3

100234-59-1

65236-62-6

Literature: Ohmoto; Koike; Higuchi; Ikeda Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 8 p. 3356 - 3360

Precursor 2
186581-53-3 100234-59-1
DownStream 0

65236-62-6	120020-18-0
30467-79-9	245662-13-9
82652-19-5	69833-11-0
123674-48-6	63086-86-2
41303-25-7	32358-82-0