Top Suppliers:I want be here
Related CAS#:
65236-62-6 120020-18-0
30467-79-9 245662-13-9
82652-19-5 69833-11-0
123674-48-6 63086-86-2
41303-25-7 32358-82-0
2248277-73-6 2248258-88-8
2248287-40-1 2248318-43-4
2248273-53-0 2448161-37-1
2248384-42-9 2248384-50-9
1823407-81-3 2248388-43-2

65236-62-6

65236-62-6 structure
65236-62-6 structure
  • Name: 4,8-Dimethoxy-1-vinyl-9H-β-carboline
  • Chemical Name: 1-ethenyl-4,8-dimethoxy-9H-pyrido[3,4-b]indole
  • CAS Number: 65236-62-6
  • Molecular Formula: C15H14N2O2
  • Molecular Weight: 254.284
  • Catalog: Natural product Alkaloid
  • Create Date: 2017-06-17 05:27:50
  • Modify Date: 2025-09-11 18:10:47
  • Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[1][2].
Name 1-ethenyl-4,8-dimethoxy-9H-pyrido[3,4-b]indole
Synonyms 9H-Pyrido[3,4-b]indole, 1-ethenyl-4,8-dimethoxy-
4,8-Dimethoxy-1-vinyl-9H-β-carboline
8-O-methylpicrasidine I
1-ethenyl-4,8-dimethoxy-9H-β-carboline
Dehydrocrenatidin
Description Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[1][2].
Related Catalog
In Vitro Dehydrocrenatidine inhibits JAK-STAT3 dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine inhibits JAKs-JH1 domain over-expression induced STAT3 and STAT1 phosphorylations[1]. Dehydrocrenatidine diminishes IL-6, IFNα and IFNγ stimulated STAT3 phosphorylation as well as constitutive STAT3 phosphorylation[1]. DHCT suppresses both tetrodotoxin-resistant (TTX-R) and sensitive (TTX-S) voltage-gated sodium channel (VGSC) currents with IC50 values of 12.36 µM and 4.87 µM, respectively[2].
In Vivo Dehydrocrenatidine inhibits JAK-STAT3 dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine inhibits JAKs-JH1 domain over-expression induced STAT3 and STAT1 phosphorylations[1]. Dehydrocrenatidine diminishes IL-6, IFNα and IFNγ stimulated STAT3 phosphorylation as well as constitutive STAT3 phosphorylation[1]. DHCT suppresses both tetrodotoxin-resistant (TTX-R) and sensitive (TTX-S) voltage-gated sodium channel (VGSC) currents with IC50 values of 12.36 µM and 4.87 µM, respectively[2].
References

[1]. Jing Zhang, et al. Dehydrocrenatidine is a novel janus kinase inhibitor. Mol Pharmacol. 2015 Apr;87(4):572-81.

[2]. Fang Zhao, et al. Dehydrocrenatidine Inhibits Voltage-Gated Sodium Channels and Ameliorates Mechanic Allodia in a Rat Model of Neuropathic Pain. Toxins (Basel). 2019 Apr 18;11(4):229.
Density 1.3±0.1 g/cm3
Boiling Point 491.8±40.0 °C at 760 mmHg
Molecular Formula C15H14N2O2
Molecular Weight 254.284
Flash Point 174.9±17.6 °C
Exact Mass 254.105530
PSA 47.14000
LogP 3.70
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.703
Hazard Codes Xi
Precursor  2

DownStream  0

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Chemsrc provides CAS#:65236-62-6 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 65236-62-6 | Chemsrc address: https://m.chemsrc.com/en/baike/525358.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved