- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: 4,8-Dimethoxy-1-vinyl-9H-β-carboline
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- BioBioPha
- China
- Product Name: Dehydrocrenatidine
- Price: ￥3900.0/5mg
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Xueping-Zheng
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: 4,8-Dimethoxy-1-vinyl-9H-β-carboline
- Price: ￥4000.0/5mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Dehydrocrenatidine
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: DEHYDROCRENATIDINE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
65236-62-6
65236-62-6 structure
- Name: 4,8-Dimethoxy-1-vinyl-9H-β-carboline
- Chemical Name: 1-ethenyl-4,8-dimethoxy-9H-pyrido[3,4-b]indole
- CAS Number: 65236-62-6
- Molecular Formula: C15H14N2O2
- Molecular Weight: 254.284
- Catalog: Natural product Alkaloid
- Create Date: 2017-06-17 05:27:50
- Modify Date: 2024-01-08 16:40:20
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Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[1][2].
| Name | 1-ethenyl-4,8-dimethoxy-9H-pyrido[3,4-b]indole |
|---|---|
| Synonyms |
9H-Pyrido[3,4-b]indole, 1-ethenyl-4,8-dimethoxy-
4,8-Dimethoxy-1-vinyl-9H-β-carboline 8-O-methylpicrasidine I 1-ethenyl-4,8-dimethoxy-9H-β-carboline Dehydrocrenatidin |
| Description | Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Dehydrocrenatidine inhibits JAK-STAT3 dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine inhibits JAKs-JH1 domain over-expression induced STAT3 and STAT1 phosphorylations[1]. Dehydrocrenatidine diminishes IL-6, IFNα and IFNγ stimulated STAT3 phosphorylation as well as constitutive STAT3 phosphorylation[1]. DHCT suppresses both tetrodotoxin-resistant (TTX-R) and sensitive (TTX-S) voltage-gated sodium channel (VGSC) currents with IC50 values of 12.36 µM and 4.87 µM, respectively[2]. |
| In Vivo | Dehydrocrenatidine inhibits JAK-STAT3 dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine inhibits JAKs-JH1 domain over-expression induced STAT3 and STAT1 phosphorylations[1]. Dehydrocrenatidine diminishes IL-6, IFNα and IFNγ stimulated STAT3 phosphorylation as well as constitutive STAT3 phosphorylation[1]. DHCT suppresses both tetrodotoxin-resistant (TTX-R) and sensitive (TTX-S) voltage-gated sodium channel (VGSC) currents with IC50 values of 12.36 µM and 4.87 µM, respectively[2]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 491.8±40.0 °C at 760 mmHg |
| Molecular Formula | C15H14N2O2 |
| Molecular Weight | 254.284 |
| Flash Point | 174.9±17.6 °C |
| Exact Mass | 254.105530 |
| PSA | 47.14000 |
| LogP | 3.70 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.703 |
| Hazard Codes | Xi |
|---|
|
~%
65236-62-6 |
| Literature: Ohmoto; Koike; Higuchi; Ikeda Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 8 p. 3356 - 3360 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |