(+)-Magnoflorine chloride

Modify Date: 2024-01-02 08:34:14

(+)-Magnoflorine chloride structure	Common Name	(+)-Magnoflorine chloride
	CAS Number	6681-18-1	Molecular Weight	377.862
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₄ClNO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (+)-Magnoflorine chloride

Magnoflorine chloride (Magnoflorine chloride), an aporphine alkaloid found in Acoruscalamus, reduces the formation of C. albicans biofilm[1]. Magnoflorine chloride has anti-fungal, anti-antidiabetic and anti-oxidative activity[2].

Name	Magnoflorine chloride
Synonym	More Synonyms

Description	Magnoflorine chloride (Magnoflorine chloride), an aporphine alkaloid found in Acoruscalamus, reduces the formation of C. albicans biofilm[1]. Magnoflorine chloride has anti-fungal, anti-antidiabetic and anti-oxidative activity[2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Metabolic Disease
References	[1]. Kim J, et al. Antifungal activity of magnoflorine against Candida strains. World J Microbiol Biotechnol. 2018 Oct 31;34(11):167. [2]. Haque MA, et al. Magnoflorine Enhances LPS-Activated Pro-Inflammatory Responses via MyD88-Dependent Pathways in U937 Macrophages. Planta Med. 2018 Nov;84(17):1255-1264.

Description

Related Catalog

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Research Areas >> Metabolic Disease

References

[1]. Kim J, et al. Antifungal activity of magnoflorine against Candida strains. World J Microbiol Biotechnol. 2018 Oct 31;34(11):167.

[2]. Haque MA, et al. Magnoflorine Enhances LPS-Activated Pro-Inflammatory Responses via MyD88-Dependent Pathways in U937 Macrophages. Planta Med. 2018 Nov;84(17):1255-1264.

Molecular Formula	C₂₀H₂₄ClNO₄
Molecular Weight	377.862
Exact Mass	377.139374
PSA	58.92000
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CE0970000

CHEMICAL NAME :: 6a-alpha-Aporphinium, 1,11-dihydroxy-2,10-dimethoxy-6-methyl-, chloride

CAS REGISTRY NUMBER :: 6681-18-1

LAST UPDATED :: 198406

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H24-N-O4.Cl

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 19600 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 7,135,1958