Lys- [Des-Arg9] Bradykinin

Modify Date: 2024-01-02 13:25:20

Lys- [Des-Arg9] Bradykinin structure	Common Name	Lys- [Des-Arg9] Bradykinin
	CAS Number	71800-36-7	Molecular Weight	1032.20
	Density	1.45g/cm3	Boiling Point	N/A
	Molecular Formula	C₅₀H₇₃N₁₃O₁₁	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Lys- [Des-Arg9] Bradykinin

Lys-[Des-Arg9]Bradykinin, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a Ki of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin has low inhibitory activity on B2 receptors[1][2].

Name	Lys-[Des-Arg9]Bradykinin
Synonym	More Synonyms

Description	Lys-[Des-Arg9]Bradykinin, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a Ki of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin has low inhibitory activity on B2 receptors[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Bradykinin Receptor
In Vitro	Lys-[Des-Arg9]Bradykinin 由缓激肽的蛋白水解裂解形成，通过缓激肽 B1 受体 (B1R) 发挥作用[1]。 Lys-[Des-Arg9]Bradykinin (Lda-BK; 10 μM) 增强 IL-12p70 的分泌并抑制成熟 hMo-DC 的 IL-12p40 分泌。用 Lys-[Des-Arg9]Bradykinin 预处理可减少成熟 hMo-DC 单独向培养基的迁移，表明 Lys-[Des-Arg9]Bradykinin 可抑制成熟 hMo-DC 的趋化作用[1]。
In Vivo	Lys-[Des-Arg9]Bradykinin (1 μg；鼻腔注射；新西兰大白兔) 处理可降低脂多糖诱导家兔外周血管阻力，但效果短暂(T1/2=118-195 s)[3]。
References	[1]. Rosalind Gulliver, et al. Lys-des[Arg9]-bradykinin alters migration and production of interleukin-12 in monocyte-derived dendritic cells. Am J Respir Cell Mol Biol. 2011 Sep;45(3):542-9. [2]. L M Fredrik Leeb-Lundberg, et al. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev. 2005 Mar;57(1):27-77. [3]. G Drapeau, et al. Hypotensive effects of Lys-des-Arg9-bradykinin and metabolically protected agonists of B1 receptors for kinins. J Pharmacol Exp Ther. 1991 Dec;259(3):997-1003.

Density	1.45g/cm3
Molecular Formula	C₅₀H₇₃N₁₃O₁₁
Molecular Weight	1032.20
Exact Mass	1031.56000
PSA	377.90000
LogP	1.65640
Index of Refraction	1.678
Storage condition	−20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

Potentiation of des-Arg9-kallidin-induced vasoconstrictor responses by metallopeptidase inhibition in isolated human umbilical artery.

J. Pharmacol. Exp. Ther. 313(3) , 1355-60, (2005)

Several metallopeptidases have been reported to be involved in bradykinin (BK) B(1) receptor agonist metabolism. Our goal was to evaluate in vitro roles of metallopeptidases [e.g., neutral endopeptida...

Kinins and neuroinflammation: dual effect on prostaglandin synthesis.

Eur. J. Pharmacol. 546(1-3) , 197-200, (2006)

The role of kinins, well known as peripheral inflammatory mediators, in the modulation of brain inflammation is unclear. The present data show that bradykinin, a bradykinin B(2) receptor agonist, enha...

Essential role of TM V and VI for binding the C-terminal sequences of Des-Arg-kinins.

Int. Immunopharmacol. 8(2) , 282-8, (2008)

In the kallikrein-kinin and renin-angiotensin systems the main receptors, B1 and B2 (kinin receptors) and AT1 and AT2 (angiotensin receptors) respectively, are seven-transmembrane domain G-protein-cou...

lysyl-des-arg9-bradykinin

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lys-arg-pro-pro-gly-phe-ser-pro-phe

MFCD00079826

Lys-[Des-Arg9]-Bradykinin