ZJ 43

Modify Date: 2024-01-02 09:53:37

ZJ 43 Structure
ZJ 43 structure
Common Name ZJ 43
CAS Number 723331-20-2 Molecular Weight 304.30
Density N/A Boiling Point N/A
Molecular Formula C12H20N2O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ZJ 43


ZJ43 is a potent NAAG peptidase inhibitor, with an IC50 of 2.4 nM and a Ki of 0.8 nM. ZJ43 sufficiently activates group II mGluR and reduces some of the behavioral effects of PCP. ZJ43 shows an analgesic effect in neuropathic and inflammatory and pain models[1].

 Names

Name (2S)-2-[[(1S)-1-carboxy-3-methylbutyl]carbamoylamino]pentanedioic acid
Synonym More Synonyms

 ZJ 43 Biological Activity

Description ZJ43 is a potent NAAG peptidase inhibitor, with an IC50 of 2.4 nM and a Ki of 0.8 nM. ZJ43 sufficiently activates group II mGluR and reduces some of the behavioral effects of PCP. ZJ43 shows an analgesic effect in neuropathic and inflammatory and pain models[1].
Related Catalog
Target

IC50: 2.4 nM (NAAG)[1]

References

[1]. Olszewski RT, et al. NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. J Neurochem. 2004 May;89(4):876-85.

[2]. Yamamoto T, et al. Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model. Eur J Neurosci. 2004 Jul;20(2):483-94.

 Chemical & Physical Properties

Molecular Formula C12H20N2O7
Molecular Weight 304.30
Exact Mass 304.12700
PSA 153.03000
LogP 0.88470

 Synonyms

zj 43
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