Phentolamine hydrochloride
Phentolamine hydrochloride structure
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Common Name | Phentolamine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 73-05-2 | Molecular Weight | 317.813 | |
| Density | N/A | Boiling Point | 569ºC at 760 mmHg | |
| Molecular Formula | C17H20ClN3O | Melting Point | >230ºC(dec.) | |
| MSDS | Chinese USA | Flash Point | 297.9ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4.
Br. J. Pharmacol. 171(23) , 5361-75, (2014) This study examined the role of the main vascular cAMP-hydrolysing phosphodiesterases (cAMP-PDE) in the regulation of basal vascular tone and relaxation of rat aorta mediated by β-adrenoceptors, following heart failure (HF).Twenty-two weeks after proximal aor... |
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Arc-Expressing Neuronal Ensembles Supporting Pattern Separation Require Adrenergic Activity in Anterior Piriform Cortex: An Exploration of Neural Constraints on Learning.
J. Neurosci. 35 , 14070-5, (2015) Arc ensembles in adult rat olfactory bulb (OB) and anterior piriform cortex (PC) were assessed after discrimination training on highly similar odor pairs. Nonselective α- and β-adrenergic antagonists or saline were infused in the OB or anterior PC during trai... |
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Noradrenaline-mediated facilitation of inhibitory synaptic transmission in the dorsal horn of the rat spinal cord involves interlaminar communications.
Eur. J. Neurosci. 42 , 2654-65, (2015) In the dorsal horn of the spinal cord (DH), noradrenaline (NA) is released by axons originating from the locus coeruleus and induces spinal analgesia, the mechanisms of which are poorly understood. Here, the effects of NA on synaptic transmission in the deep ... |
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Norepinephrine and Epinephrine Enhanced the Infectivity of Enterovirus 71.
PLoS ONE 10 , e0135154, (2015) Enterovirus 71 (EV71) infections may be associated with neurological complications, including brainstem encephalitis (BE). Severe EV71 BE may be complicated with autonomic nervous system (ANS) dysregulation and/or pulmonary edema (PE). ANS dysregulation is re... |
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Norepinephrine potentiates proinflammatory responses of human vaginal epithelial cells.
J. Neuroimmunol. 259(1-2) , 8-16, (2013) The vaginal epithelium provides a barrier to pathogens and recruits immune defenses through the secretion of cytokines and chemokines. Several studies have shown that mucosal sites are innervated by norepinephrine-containing nerve fibers. Here we report that ... |
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Pharmacological basis for the medicinal use of Wrightia tinctoria in hypertension and dyslipidemia.
J. Cardiovasc. Pharmacol. 64(2) , 151-63, (2014) This study was aimed to offer a possible pharmacological basis regarding the remedial utilization of Wrightia tinctoria in hypertension and dyslipidemia in certain South Asian traditional systems of medicine, using in vivo and in vitro assays. The aqueous met... |
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Noradrenergic but not cholinergic modulation of olfactory bulb during processing of near threshold concentration stimuli.
Behav. Neurosci. 126(5) , 720-8, (2012) Neuromodulatory systems such as noradrenaline (NE), acetylcholine (ACh), and serotonin (5HT) serve important functions in sensory perception. We use the olfactory bulb (OB) as a model system to study the roles of individual neuromodulators in sensory percepti... |
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Attenuated aortic vasodilation and sympathetic prejunctional facilitation in epinephrine-deficient mice: selective impairment of β2-adrenoceptor responses.
J. Pharmacol. Exp. Ther. 351(2) , 243-9, (2014) It has been suggested that there is a link between epinephrine synthesis and the development of β2-adrenoceptor-mediated effects, but it remains to be determined whether this development is triggered by epinephrine. The aim of this study was to characterize β... |
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Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in APP/PS1 transgenic mice.
Neuroscience 176 , 396-407, (2011) Degeneration of locus ceruleus (LC) neurons and subsequent reduction of norepinephrine (NE) in LC projection areas represent an early pathological indicator of Alzheimer's disease (AD). In order to study the effects of NE depletion on cortical and hippocampal... |
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Effects of phentolamine infusion during selective cerebral perfusion in neonatal piglets.
Ann. Thorac. Surg. 96(6) , 2203-9, (2013) An optimal selective cerebral perfusion protocol in pediatric cardiac surgery is unknown. Phentolamine is frequently used in pediatric cardiopulmonary bypass. We sought to determine the effects of continuous phentolamine infusion during selective cerebral per... |