Methotrexate disodium
Modify Date: 2024-01-09 16:54:43
Methotrexate disodium structure
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Common Name | Methotrexate disodium | ||
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| CAS Number | 7413-34-5 | Molecular Weight | 498.403 | |
| Density | N/A | Boiling Point | 823℃ | |
| Molecular Formula | C20H20N8Na2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Methotrexate disodiumMethotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3]. |
| Name | Methotrexate disodium salt |
|---|---|
| Synonym | More Synonyms |
| Description | Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3]. |
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| Related Catalog | |
| Target |
Traditional Cytotoxic Agents |
| In Vivo | Methotrexate (Amethopterin) disodium reduces thymus and spleen indices of mice. Methotrexate disodium markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice[2]. Methotrexate (MTX) disodium (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate disodium (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity[4]. |
| References |
[2]. Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92. [3]. Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92. |
| Boiling Point | 823℃ |
|---|---|
| Molecular Formula | C20H20N8Na2O5 |
| Molecular Weight | 498.403 |
| Exact Mass | 498.135193 |
| PSA | 216.20000 |
| Storage condition | -20℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| HS Code | 2933990090 |
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~87%
Methotrexate di... CAS#:7413-34-5 |
| Literature: KOCAK FARMA ILAC VE KIMYA SAN. A.S; KOCAK, Ender; ASLAN, Tuncer Patent: WO2012/74496 A1, 2012 ; Location in patent: Page/Page column 12-13 ; |
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~%
Methotrexate di... CAS#:7413-34-5 |
| Literature: Journal of Materials Chemistry, , vol. 20, # 42 p. 9463 - 9469 |
![dicyanomethyl N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate structure](https://image.chemsrc.com/caspic/451/1379609-57-0.png)
| Precursor 1 | |
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| DownStream 1 | |
![L-Glutamic acid, N-[4-[[N-(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, bis[(2, 6-dichlorophenyl)methyl] ester structure](https://image.chemsrc.com/caspic/449/86669-36-5.png)
CAS#:86669-36-5| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| METHOTREXATE DISODIUM |
| 4-amino-n(sup10)-methylpteroylglutamicaciddisodiumsalt |
| mtxdisodium |
| Methotrexate Disodium Salt Solution |
| Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, sodium salt (1:2) |
| amethopterinsodium |
| Disodium 2-[(4-{[(2,4-diamino-6-pteridinyl)methyl](methyl)amino}benzoyl)amino]pentanedioate |
| METHOTREXATUM |
| disodiummethotrexate |
| sodium methotrexate |
| N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamatic acid disodium |
| l-(+)-isodiumsal |