Manoalide

Modify Date: 2024-01-08 12:27:12

Manoalide structure	Common Name	Manoalide
	CAS Number	75088-80-1	Molecular Weight	416.550
	Density	1.1±0.1 g/cm3	Boiling Point	609.6±55.0 °C at 760 mmHg
	Molecular Formula	C₂₅H₃₆O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	203.3±25.0 °C

Use of Manoalide

Manoalide is a potent Phospholipase A2 (PLA2) and Phospholipase C (PLC) inhibitor. Manoalide, a sesterpenoid compound, displays anti-inflammatory and antibacterial activities[1][2][3].

Name	manoalide
Synonym	More Synonyms

Description	Manoalide is a potent Phospholipase A2 (PLA2) and Phospholipase C (PLC) inhibitor. Manoalide, a sesterpenoid compound, displays anti-inflammatory and antibacterial activities[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
Target	PLA2 PLC
In Vitro	Manoalide (0.05 μM) impaires IL-7-induced entry of the B cell progenitors into S and G2/M phases and increases the population of apoptotic cells in IL-7-cultured B cell progenitors. In addition, Manoalide reduced IL-7-induced phosphorylation of S6 compared to the control without inhibitor pre-treatment[1].
In Vivo	Manoalide reverses venom preconditioning (VPC)-induced anti-inflammatory effects 24 h after surgical brain injury (SBI) in adult male Sprague-Dawley rats, 260 to 300 g[1].
References	[1]. Mei Yu, et al. PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development. Nat Commun. 2017 Nov 13;8(1):1457. [2]. Yuechun Wang, et al. Naja sputatrix Venom Preconditioning Attenuates Neuroinflammation in a Rat Model of Surgical Brain Injury via PLA2/5-LOX/LTB4 Cascade Activation. Sci Rep. 2017 Jul 14;7(1):5466. [3]. Afef Dellai, et al. Anticonvulsant and analgesic activities of crude extract and its fractions of the defensive secretion from the Mediterranean sponge, Spongia officinalis. Cancer Cell Int. 2012 Apr 11;12(1):15.

Density	1.1±0.1 g/cm3
Boiling Point	609.6±55.0 °C at 760 mmHg
Molecular Formula	C₂₅H₃₆O₅
Molecular Weight	416.550
Flash Point	203.3±25.0 °C
Exact Mass	416.256287
PSA	75.99000
LogP	5.19
Vapour Pressure	0.0±4.0 mmHg at 25°C
Index of Refraction	1.549

Hazard Codes	Xn: Harmful;
Risk Phrases	20/22
Safety Phrases	36

Precursor 6
CAS#:105498-76-8 seco-manoalide CAS#:130493-22-0 5-triethylsilyl... CAS#:105426-92-4 4-((7E)-4-(dime... CAS#:4179-00-4 Methyl (E)-3-me...
CAS#:18665-81-1 (E)-3-methyl-5-... CAS#:29550-53-6 (E)-3-methyl-5-...
DownStream 0

Manoalide

MFCD00153826

(5R)-5-Hydroxy-4-{(2R,6R)-6-hydroxy-5-[(3E)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-hexen-1-yl]-3,6-dihydro-2H-pyran-2-yl}-2(5H)-furanone

2(5H)-Furanone, 4-[(2R,6R)-3,6-dihydro-6-hydroxy-5-[(3E)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-hexen-1-yl]-2H-pyran-2-yl]-5-hydroxy-, (5R)-

(2R)-2-hydroxy-3-[(2R,6R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,6-trimethylcyclohexen-1-yl)hex-3-enyl]-3,6-dihydro-2H-pyran-2-yl]-2H-furan-5-one

DC Chemicals Limited
China
Product Name: Manoalide
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: MANOALIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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