DM4
Modify Date: 2024-01-28 12:54:50
DM4 structure
|
Common Name | DM4 | ||
|---|---|---|---|---|
| CAS Number | 796073-69-3 | Molecular Weight | 780.36700 | |
| Density | 1.29±0.1 g/cm3 | Boiling Point | 943.2±65.0 °C | |
| Molecular Formula | C38H54ClN3O10S | Melting Point | 185-187 °C (decomp) | |
| MSDS | N/A | Flash Point | N/A | |
Use of DM4DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate. |
| Name | N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine |
|---|---|
| Synonym | More Synonyms |
| Description | DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody drug conjugate. |
|---|---|
| Related Catalog | |
| In Vitro | DM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death[1]. |
| References |
| Density | 1.29±0.1 g/cm3 |
|---|---|
| Boiling Point | 943.2±65.0 °C |
| Melting Point | 185-187 °C (decomp) |
| Molecular Formula | C38H54ClN3O10S |
| Molecular Weight | 780.36700 |
| Exact Mass | 779.32200 |
| PSA | 195.27000 |
| LogP | 5.39690 |
| Hazard Codes | T+ |
|---|
| l-dm4 |
| n2'-deacetyl-n2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine |
| DM4 |