Small Cardioactive Peptide B (SCPB)

Modify Date: 2024-01-03 10:08:42

Small Cardioactive Peptide B (SCPB) Structure
Small Cardioactive Peptide B (SCPB) structure
 Common Name Small Cardioactive Peptide B (SCPB)
CAS Number 84746-43-0 Molecular Weight 1141.41000
Density 1.41 g/cm3 Boiling Point N/A
Molecular Formula C52H80N14O11S2 Melting Point N/A
MSDS N/A Flash Point N/A
Purity Quantity Budget Inquiry

 Use of Small Cardioactive Peptide B (SCPB)


Small Cardioactive Peptide B (SCPB), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC50s of 0.1 and 1.0 μM, respectively.

 Names

Name scpb
Synonym More Synonyms

 Small Cardioactive Peptide B (SCPB) Biological Activity

Description Small Cardioactive Peptide B (SCPB), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC50s of 0.1 and 1.0 μM, respectively.
Related Catalog
Target

EC50: 0.1 μM (adenylate cyclase, in heart tissues), 1.0 μM (adenylate cyclase, in gill tissues)[1]

In Vitro Small cardioactive peptide B (SCPB) is a neurally active peptide endogenous to Aplysia. Small cardioactive peptide B (SCPB) possesses cardioexcitatory effects in Aplysia and reported a threshold concentration of 0.01 nM for both native and synthetic Small cardioactive peptide B (SCPB) stimulated effects on the isolated heart. Effects of Small Cardioactive Peptide B (SCPB) on the physiology of the isolated heart and gill preparations from the mollusc Aplysia californica were examined. In addition, the effects of Small Cardioactive Peptide B (SCPB) and FMRFamide (Phe-Met-Arg-Phe-NH2) on adenylate cyclase activity are compared in particulate fractions of heart and gill tissues, respectively. Small Cardioactive Peptide B (SCPB) is found to exert dose-dependent, reversible changes in cardiac activity when perfused through the isolated heart. The EC50 values effecting changes in heart rate and force of contraction are 0.03 and 0.3 nM, respectively; minimum concentrations find to effect changes in heart rate and force of contraction are normally 0.001 and 1 pM, respectively. When perfused through the isolated gill, Small Cardioactive Peptide B (SCPB) is found to suppress the gill withdrawal response amplitude with a threshold concentration of 0.01 pM and an EC50 value of 0.03 nM. Suppression of the gill withdrawal response amplitude by Small Cardioactive Peptide B (SCPB)is found to be dose dependent and reversible up to a concentration of 1nM. At higher concentrations, the suppression tended to persist irreversibly. Small Cardioactive Peptide B (SCPB) stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with an EC50 of 0.1 and 1.0μM, respectively[1].
References

[1]. Cawthorpe DR, et al. The effects of small cardioactive peptide B on the isolated heart and gill of Aplysia californica. Can J Physiol Pharmacol. 1985 Aug;63(8):918-24.

 Chemical & Physical Properties

Density 1.41 g/cm3
Molecular Formula C52H80N14O11S2
Molecular Weight 1141.41000
Exact Mass 1140.56000
PSA 468.94000
LogP 4.05150
Index of Refraction 1.656
Storage condition 2-8℃

 Safety Information

WGK Germany 3

 Synonyms

met-asn--leu-ala-phe-pro-arg-met (met-asn-tyr-leu-ala-phe-pro-arg-met amide)
small cardioactive peptide b
cardioactive peptide b (small)
h-met-asn-tyr-leu-ala-phe-pro-arg-met-nh2
met-asn-tyr-leu-ala-phe-pro-arg-met amide
met-asn-tyr-leu-ala-phe-pro-arg-met-nh2
mnylafprm-nh2
MET-ASN-TYR-LEU-ALA-PHE-PRO-ARG-MET-NH2
Small Cardioactive Peptide B (SCPB)
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