Azido-PEG8-NHS ester
Modify Date: 2024-01-07 10:30:31
Azido-PEG8-NHS ester structure
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Common Name | Azido-PEG8-NHS ester | ||
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| CAS Number | 1204834-00-3 | Molecular Weight | 564.58300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H40N4O12 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Azido-PEG8-NHS esterAzido-PEG8-NHS ester is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2]. |
| Name | 2,5-dioxopyrrolidin-1-yl 1-azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oate |
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| Description | Azido-PEG8-NHS ester is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[2]. |
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| Related Catalog | |
| Target |
PEGs Alkyl/ether Cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
[1]. Mahendra Persaud Deonarain, et al. Biological materials and uses thereof. WO2016046574A1. |
| Molecular Formula | C23H40N4O12 |
|---|---|
| Molecular Weight | 564.58300 |
| Exact Mass | 564.26400 |
| PSA | 187.27000 |
| Storage condition | -20°C |