HS-PEG8-CH2CH2COOH

Modify Date: 2024-01-13 17:16:46

HS-PEG8-CH2CH2COOH Structure
HS-PEG8-CH2CH2COOH structure
Common Name HS-PEG8-CH2CH2COOH
CAS Number 866889-02-3 Molecular Weight 458.56400
Density N/A Boiling Point N/A
Molecular Formula C19H38O10S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HS-PEG8-CH2CH2COOH


Thiol-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 3-[2-[2-[2-[2-[2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Synonym More Synonyms

 HS-PEG8-CH2CH2COOH Biological Activity

Description Thiol-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C19H38O10S
Molecular Weight 458.56400
Exact Mass 458.21900
PSA 149.94000
LogP 0.52370

 Safety Information

Hazard Codes Xi

 Synonyms

AmbotzPEG1120
PEG thiol acid
4,7,10,13,16,19,22,25-Octaoxaheptacosanoicacid,27-mercapto