m-PEG3-NHS ester

Modify Date: 2024-01-11 15:53:38

m-PEG3-NHS ester Structure
m-PEG3-NHS ester structure
Common Name m-PEG3-NHS ester
CAS Number 876746-59-7 Molecular Weight 289.282
Density 1.3±0.1 g/cm3 Boiling Point 393.7±50.0 °C at 760 mmHg
Molecular Formula C12H19NO7 Melting Point N/A
MSDS N/A Flash Point 191.9±30.1 °C

 Use of m-PEG3-NHS ester


m-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

 Names

Name 1-({3-[2-(2-Methoxyethoxy)ethoxy]propanoyl}oxy)-2,5-pyrrolidinedione
Synonym More Synonyms

 m-PEG3-NHS ester Biological Activity

Description m-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Related Catalog
In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 393.7±50.0 °C at 760 mmHg
Molecular Formula C12H19NO7
Molecular Weight 289.282
Flash Point 191.9±30.1 °C
Exact Mass 289.116150
LogP -2.51
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.491

 Safety Information

Hazard Codes Xi

 Synonyms

2,5-Pyrrolidinedione, 1-[3-[2-(2-methoxyethoxy)ethoxy]-1-oxopropoxy]-
1-({3-[2-(2-Methoxyethoxy)ethoxy]propanoyl}oxy)-2,5-pyrrolidinedione
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