Naloxonazine dihydrochloride
Modify Date: 2024-04-01 18:49:59
Naloxonazine dihydrochloride structure
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Common Name | Naloxonazine dihydrochloride | ||
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| CAS Number | 880759-65-9 | Molecular Weight | 687.22400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C38H43ClN4O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of Naloxonazine dihydrochlorideNaloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC50 of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity[1][2][3]. |
| Name | Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, [(5α)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]hydrazone, dihydrochloride, (5α) |
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| Synonym | More Synonyms |
| Description | Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC50 of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity[1][2][3]. |
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| Related Catalog | |
| Target |
μ-opioid receptor:5.4 nM (IC50) |
| In Vitro | Naloxonazine is relatively stable in solution[2]. Naloxonazine (72 h) is active against the intracellular amastigote stage of Leishmania donovani with a half maximal inhibitory concentration (GI50) of 3.45 μM[3]. Naloxonazine (10 μM; 0-72 h) is active at early stages of Leishmania donovani infection[3]. Naloxonazine affects acidic compartments of the host cell which in turn limit L. donovani intracellular growth[3]. |
| In Vivo | Naloxonazine (20 mg/kg; i.p.; once) attenuates the increment of locomotor activity induced by acute methamphetamine in mice[1] Animal Model: Male ICR mice, methamphetamine (METH)-induced locomotor activity model[1] Dosage: 20 mg/kg Administration: Intraperitoneal injection, once, 60 min before injecting saline (i.p.) or METH (1 mg/kg, i.p.) Result: Significantly attenuated the acute METH-induced increase in locomotor activity and phosphor-Thr75 DARPP-32 levels. |
| References |
| Molecular Formula | C38H43ClN4O6 |
|---|---|
| Molecular Weight | 687.22400 |
| Exact Mass | 686.28700 |
| PSA | 130.58000 |
| LogP | 3.95300 |
| NALOXONAZINE DIHYDROCHLORIDE HYDRATE |
| NALOXONAZINE DIHYDROCHLORIDE OPIOID ANTA GONIST |
| Naloxonazine dihydrochloride |
| Demethylasterriquinone B1 |