SARS-CoV-IN-1

Modify Date: 2024-01-09 17:32:56

SARS-CoV-IN-1 Structure
SARS-CoV-IN-1 structure
Common Name SARS-CoV-IN-1
CAS Number 888958-25-6 Molecular Weight 441.69
Density N/A Boiling Point N/A
Molecular Formula C23H16ClFeN3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SARS-CoV-IN-1


SARS-CoV-IN-1 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-1 shows anti-Coronavirus activity with an EC50 of 4.9 μM in Vero cells. SARS-CoV-IN-1 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 15.4 and 133.2 nM; and IC90s of 25.7 and 459.1 nM; respectively. Antimalarial and antiviral activities[1].

 Names

Name SARS-CoV-IN-1

 SARS-CoV-IN-1 Biological Activity

Description SARS-CoV-IN-1 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-1 shows anti-Coronavirus activity with an EC50 of 4.9 μM in Vero cells. SARS-CoV-IN-1 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 15.4 and 133.2 nM; and IC90s of 25.7 and 459.1 nM; respectively. Antimalarial and antiviral activities[1].
Related Catalog
Target

EC50: 4.9 μM (SARS-CoV, in Vero cells)[1] IC50: 15.4 nM (3D7 P. falciparum), 133.2 nM (W2 P. falciparum)[1] IC90: 25.7 nM (3D7 P. falciparum), 459.1 nM (W2 P. falciparum)[1]

In Vitro SARS-CoV-IN-1 (Compound 2) inhibits in vitro growth of Plasmodium falciparum far better than Chloroquine (CQ) [1].
References

[1]. Biot C, et al. Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities. J Med Chem. 2006 May 4;49(9):2845-9.

 Chemical & Physical Properties

Molecular Formula C23H16ClFeN3O
Molecular Weight 441.69
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