SARS-CoV-IN-2

Modify Date: 2024-01-09 23:05:14

SARS-CoV-IN-2 Structure
SARS-CoV-IN-2 structure
Common Name SARS-CoV-IN-2
CAS Number 888958-26-7 Molecular Weight 455.72
Density N/A Boiling Point N/A
Molecular Formula C24H18ClFeN3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SARS-CoV-IN-2


SARS-CoV-IN-2 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC50 of 1.9 μM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 21.5 and 30 nM; and IC90s of 51.0 and 99.9 nM; respectively. SARS-CoV-IN-2 reduces HIV-1-induced cytopathic effect with an EC50 of 2.9 μM in MT-4 cells. Antimalarial and Antiviral Activities[1].

 Names

Name SARS-CoV-IN-2

 SARS-CoV-IN-2 Biological Activity

Description SARS-CoV-IN-2 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC50 of 1.9 μM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 21.5 and 30 nM; and IC90s of 51.0 and 99.9 nM; respectively. SARS-CoV-IN-2 reduces HIV-1-induced cytopathic effect with an EC50 of 2.9 μM in MT-4 cells. Antimalarial and Antiviral Activities[1].
Related Catalog
Target

EC50: 1.9 μM (SARS-CoV, in Vero cells)[1] IC50: 21.5 nM (3D7 P. falciparum), 30 nM (W2 P. falciparum)[1] IC90: 51.0 nM (3D7 P. falciparum), 99.9 nM (W2 P. falciparum)[1]

In Vitro SARS-CoV-IN-2 (Compound 3) inhibits in vitro growth of Plasmodium falciparum far better than Chloroquine (CQ) [1].
References

[1]. Biot C, et al. Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities. J Med Chem. 2006 May 4;49(9):2845-9.

 Chemical & Physical Properties

Molecular Formula C24H18ClFeN3O
Molecular Weight 455.72
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