SEC inhibitor KL-1

Modify Date: 2024-01-10 00:10:14

SEC inhibitor KL-1 structure	Common Name	SEC inhibitor KL-1
	CAS Number	900308-84-1	Molecular Weight	345.78
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₆ClNO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SEC inhibitor KL-1

SEC inhibitor KL-1 (KL-1), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 3.48 μM[1].

Name	SEC inhibitor KL-1

Description	SEC inhibitor KL-1 (KL-1), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 3.48 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	SEC[1]
References	[1]. Liang K, et al. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced CancerTherapy. Cell. 2018 Oct 18;175(3):766-779.

Molecular Formula	C₁₈H₁₆ClNO₄
Molecular Weight	345.78

DC Chemicals Limited
China
Product Name: SEC inhibitor KL-1
Price: $270.0/10mg $400.0/25mg $900.0/100mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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