Penicillin amidase
Penicillin amidase structure
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Common Name | Penicillin amidase | ||
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| CAS Number | 9014-06-6 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of Penicillin amidasePenicillin amidase (Penicillin acylase) is an enzyme that cleaves the acyl side chains of penicillins. Penicillin amidase can be used for the production of 6-aminopenicillanic acid. Penicillin amidase can also be used in the resolution of racemic mixtures, peptide synthesis, and synthesis of semi-synthetic β-lactam antibiotics[1][2][3]. |
| Name | EC 3.5.1.11 |
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| Synonym | More Synonyms |
| Description | Penicillin amidase (Penicillin acylase) is an enzyme that cleaves the acyl side chains of penicillins. Penicillin amidase can be used for the production of 6-aminopenicillanic acid. Penicillin amidase can also be used in the resolution of racemic mixtures, peptide synthesis, and synthesis of semi-synthetic β-lactam antibiotics[1][2][3]. |
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| Related Catalog | |
| References |
[3]. Tishkov VI, et al. Protein engineering of penicillin acylase. Acta Naturae. 2010 Jul;2(3):47-61. |
| Appearance of Characters | lyophilized powder |
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| Storage condition | 2-8°C |
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Structure of a class III engineered cephalosporin acylase: comparisons with class I acylase and implications for differences in substrate specificity and catalytic activity.
Biochem. J. 451(2) , 217-26, (2013) The crystal structure of the wild-type form of glutaryl-7-ACA (7-aminocephalosporanic acid) acylase from Pseudomonas N176 and a double mutant of the protein (H57βS/H70βS) that displays enhanced cataly... |
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Enantioselective acylation of β-phenylalanine acid and its derivatives catalyzed by penicillin G acylase from Alcaligenes faecalis.
Prep Biochem Biotechnol. 43(2) , 207-16, (2013) This study developed a simple, efficient method for producing racemic β-phenylalanine acid (BPA) and its derivatives via the enantioselective acylation catalyzed by the penicillin G acylase from Alcal... |
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Engineering the substrate specificity of a thermophilic penicillin acylase from thermus thermophilus.
Appl. Environ. Microbiol. 79(5) , 1555-62, (2013) A homologue of the Escherichia coli penicillin acylase is encoded in the genomes of several thermophiles, including in different Thermus thermophilus strains. Although the natural substrate of this en... |
| EINECS 232-753-8 |