6-Oxohexanoic acid

Modify Date: 2024-01-09 18:53:12

6-Oxohexanoic acid Structure
6-Oxohexanoic acid structure
 Common Name 6-Oxohexanoic acid
CAS Number 928-81-4 Molecular Weight 130.14200
Density 1.088g/cm3 Boiling Point 263.7ºC at 760mmHg
Molecular Formula C6H10O3 Melting Point N/A
MSDS N/A Flash Point 127.5ºC

 Use of 6-Oxohexanoic acid


6-Oxohexanoic acid is a non-cleavable modified MMAF-C5-COOH linker and can be used in the synthesis of modified MMAF-C5-COOH, a drug-linker conjugate for ADC[1].

 Names

Name 6-oxohexanoic acid
Synonym More Synonyms

 6-Oxohexanoic acid Biological Activity

Description 6-Oxohexanoic acid is a non-cleavable modified MMAF-C5-COOH linker and can be used in the synthesis of modified MMAF-C5-COOH, a drug-linker conjugate for ADC[1].
Related Catalog
In Vitro MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC50s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay[2].
References

[1]. Polson AG, et al. Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection [published correction appears in Cancer Res. 2010 Feb 1;70(3):1275. Slaga, Dion S [added]]. Cancer Res. 2009;69(6):2358-2364.

[2]. Doronina SO, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006;17(1):114-124.

 Chemical & Physical Properties

Density 1.088g/cm3
Boiling Point 263.7ºC at 760mmHg
Molecular Formula C6H10O3
Molecular Weight 130.14200
Flash Point 127.5ºC
Exact Mass 130.06300
PSA 54.37000
LogP 0.83030
Index of Refraction 1.441

 Safety Information

HS Code 2918300090

 Synthetic Route

 Customs

HS Code 2918300090
Summary 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Synonyms

Hexan-1-one-6-carboxylate
6-Oxohexanoate
6-OXO-HEXANOIC ACID
adipic semialdehyde
6-Oxohexanoic acid
monoaldehyde of adipic acid
6-oxo-n-hexanoic acid
1-hexanal-6-carboxylic acid
adipic acid monoaldehyde
5-carbohydroxy-1-pentanal
5-formylvaleric acid
Hexanoic acid,6-oxo
adipic monoaldehyde
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Chemsrc provides 6-Oxohexanoic acid(CAS#:928-81-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 6-Oxohexanoic acid are included as well.>> amp version: 6-Oxohexanoic acid

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