Guanosine 5′-[γ-thio]triphosphate

Modify Date: 2025-08-25 09:20:51

Guanosine 5′-[γ-thio]triphosphate Structure
Guanosine 5′-[γ-thio]triphosphate structure
Common Name Guanosine 5′-[γ-thio]triphosphate
CAS Number 94825-44-2 Molecular Weight 562.97800
Density N/A Boiling Point N/A
Molecular Formula C10H12Li4N5O13P3S Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of Guanosine 5′-[γ-thio]triphosphate


GTPγS (tetralithium) is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS (tetralithium) to couple with G- protein α, to study its effect on kinase activity. GTPγS (tetralithium) acts as a component of lysis buffer[1][2][3][4].

 Names

Name tetralithium,[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] dioxidophosphinothioyl phosphate
Synonym More Synonyms

 Guanosine 5′-[γ-thio]triphosphate Biological Activity

Description GTPγS (tetralithium) is a G-protein activator that protects proteins from proteolytic degradation, stimulates GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization. GTPγS (tetralithium) to couple with G- protein α, to study its effect on kinase activity. GTPγS (tetralithium) acts as a component of lysis buffer[1][2][3][4].
Related Catalog
References

[1]. Julie G Hensler, et al. Differential Regulation of 5-HT1A Receptor-G Protein Interactions in Brain Following Chronic Antidepressant Administration. Neuropsychopharmacology. 2002 May;26(5):565-73.  

[2]. Li-Bin Liu, et al. Insulin recruits GLUT4 from distinct compartments via distinct traffic pathways with differential microtubule dependence in rat adipocytes. J Biol Chem. 2003 Aug 8;278(32):30157-69. doi: 10.1074/jbc.M301511200.  

[3]. Xufeng Wu, et al. Rab27a is an essential component of melanosome receptor for myosin Va. Mol Biol Cell. 2002 May;13(5):1735-49.  

[4]. Pilar Sánchez-Blázquez, et al. Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway. Cell Signal. 2009 Sep;21(9):1444-54.  

 Chemical & Physical Properties

Molecular Formula C10H12Li4N5O13P3S
Molecular Weight 562.97800
Exact Mass 563.00100
PSA 354.87000
LogP 0.76530
Storage condition 20°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport

 Articles2

More Articles
Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway.

Cell Physiol. Biochem. 21 , 1444-54, (2009)

There is a certain cross-talk in the nervous system between N-methyl-D-aspartate receptors (NMDARs) and Mu-opioid receptors (MORs). While NMDARs participate in the desensitization of MORs, these in tu...

High-level production and characterization of a G-protein coupled receptor signaling complex.

FASEB J. 276 , 4515-28, (2009)

Elucidation of the molecular details of signal transduction through G-protein coupled receptors (GPCRs) awaits the solution of high-resolution structures of the receptor species involved in passing th...

 Synonyms

EINECS 305-606-1
GTP|AS tetralithium salt
MFCD00135151
GTP-|A-S-Li4
Guanosine5'-(Trihydrogen Diphosphate) P'-Anhydride With Phosphorothioic Acid Lithiumsalt (1:4)
Guanosine 5′-[γ-thio]triphosphate
Gtp-Gamma-S Tetralithium Salt
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