Metroprolol succinate

Modify Date: 2024-01-03 14:20:30

Metroprolol succinate Structure
Metroprolol succinate structure
Common Name Metroprolol succinate
CAS Number 98418-47-4 Molecular Weight 652.816
Density N/A Boiling Point 398.6ºC at 760 mmHg
Molecular Formula C34H56N2O10 Melting Point N/A
MSDS N/A Flash Point 194.9ºC
Symbol GHS08
GHS08
Signal Word Danger

 Use of Metroprolol succinate


Metoprolol Succinate (Toprol XL) is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension.IC50 value:Target: β1 receptor

 Names

Name butanedioic acid,1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
Synonym More Synonyms

 Metroprolol succinate Biological Activity

Description Metoprolol Succinate (Toprol XL) is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension.IC50 value:Target: β1 receptor
Related Catalog
References

[1]. Benfield P, et al. Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders. Drugs. 1986 May;31(5):376-429.

 Chemical & Physical Properties

Boiling Point 398.6ºC at 760 mmHg
Molecular Formula C34H56N2O10
Molecular Weight 652.816
Flash Point 194.9ºC
Exact Mass 652.393494
PSA 176.04000
LogP 3.94400
Storage condition -20℃
Water Solubility Freely soluble in water, soluble in methanol, slightly soluble in ethanol (96 per cent), very slightly soluble in ethyl acetate.

 Safety Information

Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H370
Precautionary Statements P260
HS Code 2922199090

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles1

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Prilling as manufacturing technique for multiparticulate lipid/PEG fixed-dose combinations.

Eur. J. Pharm. Biopharm. 88(2) , 472-82, (2014)

This study focused on the evaluation of prilling as a technique for the manufacturing of multiparticulate dosage forms. Prills, providing controlled and immediate drug release, were processed and fina...

 Synonyms

UNII:TH25PD4CCB
1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol butanedioate (2:1)
Selozok
1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]propan-2-ol butanedioate (2:1) (salt)
Beloc-Zok
Succinic acid - 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]-2-propanol (1:2)
2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, butanedioate (2:1) (salt)
Metroprolol succinate
Spesicor Dos
1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol succinate (2:1)
Toprol XL
acide butanedioïque - 1-[4-(2-méthoxyéthyl)phénoxy]-3-[(1-méthyléthyl)amino]propan-2-ol (1:2)
Seloken ZOC
Butandisäure--1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]propan-2-ol(1:2)
H 93/26 succinate
Metoprolol (Succinate)
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