HC Toxin
HC Toxin structure
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Common Name | HC Toxin | ||
|---|---|---|---|---|
| CAS Number | 83209-65-8 | Molecular Weight | 436.50 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 819.2±65.0 °C at 760 mmHg | |
| Molecular Formula | C21H32N4O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 449.2±34.3 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of HC ToxinHC-Toxin, a cyclic tetrapeptide, is a potent HDAC inhibitor with an IC50 of 30 nM[1]. HC-Toxin induces tumor cell apoptosis and has anticancer effects[2]. |
| Name | HC toxin |
|---|---|
| Synonym | More Synonyms |
| Description | HC-Toxin, a cyclic tetrapeptide, is a potent HDAC inhibitor with an IC50 of 30 nM[1]. HC-Toxin induces tumor cell apoptosis and has anticancer effects[2]. |
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| Related Catalog | |
| In Vitro | HC-Toxin shows potent antiproliferative efficacy and cell cycle arrest at G2/M in T47D human breast cancer cells in a dose-dependent manner. HC-Toxin evokes apoptosis of T47D cells and HC-toxin induced apoptosis might not be mediated through direct increase in caspase-3/7 activity[2]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 819.2±65.0 °C at 760 mmHg |
| Molecular Formula | C21H32N4O6 |
| Molecular Weight | 436.50 |
| Flash Point | 449.2±34.3 °C |
| Exact Mass | 436.232178 |
| PSA | 137.21000 |
| LogP | -2.99 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.562 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300 |
| Precautionary Statements | P264-P301 + P310 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| RIDADR | UN 2811 6.1 / PGIII |
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Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinoma.
Carcinogenesis 22(1) , 187-91, (2001) 15-Lipoxygenase-1 (15-LO-1) is expressed at higher levels in human colorectal tumors compared with normal tissue. 15-LO-1 is expressed in cultured human colorectal cells, but only after treatment with... |
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A putative branched-chain-amino-acid transaminase gene required for HC-toxin biosynthesis and pathogenicity in Cochliobolus carbonum.
Microbiology 145 ( Pt 12) , 3539-46, (1999) The cyclic tetrapeptide HC-toxin is required for pathogenicity of the filamentous fungus Cochliobolus carbonum on maize. HC-toxin production is controlled by a complex locus, TOX2. The isolation and c... |
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Regulation of cyclic peptide biosynthesis in a plant pathogenic fungus by a novel transcription factor.
Proc. Natl. Acad. Sci. U. S. A. 98(24) , 14174-9, (2001) Strains of the filamentous fungus Cochliobolus carbonum that produce the host-selective compound HC-toxin, a cyclic tetrapeptide, are highly virulent on certain genotypes of maize (Zea mays L.). Produ... |
| 3,6-Dimethyl-9-[6-(2-oxiranyl)-6-oxohexyl]decahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetrone |
| MFCD00133388 |
| Toxin I |
| HC TOXIN |
| Pyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetrone, decahydro-3,6-dimethyl-9-(6-oxiranyl-6-oxohexyl)- |