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双羟萘酸羟嗪

双羟萘酸羟嗪用途

双羟萘酸羟嗪 (Hydroxyzine pamoate) 是一种组胺受体 H1拮抗剂。

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双羟萘酸羟嗪名称

[ CAS 号 ]:
10246-75-0

[ 中文名 ]:
扑姆酸羟嗪

[ 英文名 ]:
Hydroxyzine (pamoate)

[中文别名 ]:

双羟萘酸羟嗪

[英文别名 ]:

Paxistil {Pamoate}
Equipose {Pamoate}
Paxisitil
Bobsule
Atarax P
Hydroxyzine pamoate salt
hydroxyzine pamoate
Hydroxyzyne pamoate
EINECS 233-582-1
Hydroxyzine embonate

双羟萘酸羟嗪生物活性

[ 描述 ]:

双羟萘酸羟嗪 (Hydroxyzine pamoate) 是一种组胺受体 H1拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 炎症/免疫

[参考文献]

[1]. Minogiannis, P., et al., Hydroxyzine inhibits neurogenic bladder mast cell activation. Int J Immunopharmacol, 1998. 20(10): p. 553-63.

[2]. Dimitriadou, V., X. Pang, and T.C. Theoharides, Hydroxyzine inhibits experimental allergic encephalomyelitis (EAE) and associated brain mast cell activation. Int J Immunopharmacol, 2000. 22(9): p. 673-84.

[3]. Kan, W.M., et al., Effect of hydroxyzine on the transport of etoposide in rat small intestine. Anticancer Drugs, 2001. 12(3): p. 267-73.

[4]. Morichi, R. and G. Pepeu, A study of the influence of hydroxyzine and diazepam on morphine antinociceptoion in the rat. Pain, 1979. 7(2): p. 173-80.

[相关活性小分子]

双羟萘酸羟嗪物理化学性质

[ 密度 ]:
1.182g/cm3

[ 沸点 ]:
499.2ºC at 760mmHg

[ 分子式 ]:
C₄₄H₄₃ClN₂O₈

[ 分子量 ]:
763.274

[ 闪点 ]:
255.7ºC

[ 精确质量 ]:
762.270813

[ PSA ]:
151.00000

[ LogP ]:
7.32310

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
2.13E-17mmHg at 25°C

[ 储存条件 ]:
-20℃

双羟萘酸羟嗪MSDS

详细MSDS(安全技术说明书)

双羟萘酸羟嗪安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

双羟萘酸羟嗪文献

Microencapsulation of hydroxyzine HCl by thermal phase separation: in vitro release enhancement and in vivo pharmacodynamic evaluation.

Pharm. Dev. Technol. 18(1) , 196-209, (2013)

The systemic effect of hydroxyzine hydrochloride following its oral administration or topical application is associated with non compliant anticholinergic effect. Subsequently, the present study aims ...

Worsening of contact dermatitis by oral hydroxyzine: a case report.

Dermatol. Online J. 19(2) , 4, (2013)

Hydroxyzine is commonly used to treat pruritic skin lesions. Although rare, hydroxyzine can sometimes be linked to worsening dermatitis in patients who have sensitivities to phenothiazines and/or ethy...

Acute generalized exanthematous pustulosis associated with 2 common medications: hydroxyzine and benzocaine.

J. Am. Acad. Dermatol. 71(4) , e147-9, (2014)

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