腐草霉素

腐草霉素用途

Phleomycin 是在链霉菌中发现的广谱糖肽类抗生素 (antibiotic) 源于链霉菌。与博莱霉素类似,它是一种有效的 DNA 裂解剂,与 DNA 结合并插入,破坏双螺旋结构的完整性。与博莱霉素 (HY-17565A) 类似,它是一种有效的 DNA 裂解剂,与 DNA 结合并插入,破坏双螺旋结构的完整性。

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腐草霉素名称

[ CAS 号 ]:
11006-33-0

[ 中文名 ]:
腐草霉素

[ 英文名 ]:
Phleomycin

[英文别名 ]:

PHLEOMYCIN
MFCD00131846
phleomycincomplex
PHLEOMYCIN (STREPTOMYCES VERTICILLUS)
phleomycin from streptomyces*verticillus
ZEOCIN(TM)

腐草霉素生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

信号通路 >> 抗感染 >> 细菌

[ 靶点 ]

IC50: Antibiotic[1]

[参考文献]

[1]. Kamila Stokowa-Sołtys, et al. Phleomycin complex - Coordination mode and in vitro cleavage of DNA. J Inorg Biochem. 2019 Jun;195:71-82.

腐草霉素物理化学性质

[ 密度 ]:
1.83 g/cm3

[ 沸点 ]:
1718.8ºC at 760 mmHg

[ 分子式 ]:
C₅₂H₇₅N₁₆O₂₁S₂

[ 分子量 ]:
1324.38000

[ 闪点 ]:
993.3ºC

[ 精确质量 ]:
1323.47000

[ PSA ]:
664.89000

[ 外观性状 ]:
light blue

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.777

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: 10 mg/mL, clear, blue

腐草霉素MSDS

详细MSDS(安全技术说明书)

腐草霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SY0525000

CHEMICAL NAME :: Phleomycin

CAS REGISTRY NUMBER :: 11006-33-0

LAST UPDATED :: 199806

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C13-H28-N3-O12

MOLECULAR WEIGHT :: 418.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 649 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 371 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg/10D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - mouse Ovary

DOSE/DURATION :: 1 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 6,289,1968

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腐草霉素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;Xi: Irritant;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
UN 2811

[ WGK德国 ]:
3

[ RTECS号 ]:
SY0525000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

腐草霉素文献

CRE recombinase-based positive-negative selection systems for genetic manipulation in Trypanosoma brucei.

Mol. Biochem. Parasitol. 157(1) , 73-82, (2008)

The limited repertoire of drug-resistance markers imposes a serious obstacle to genetic manipulation of Trypanosoma brucei. Here we describe experiments with a fusion protein that allows positive sele...

Copper(II).bleomycin, iron(III).bleomycin, and copper(II).phleomycin: comparative study of deoxyribonucleic acid binding.

Biochemistry 20 , 665-671, (1981)

The kinetics and mechanism of binding of Cu-(II).bleomycin, Fe(III).bleomycin, and Cu(II).phleomycin to DNA were studied by using fluorometry, equilibrium dialysis, electric dichroism, and temperature...

Sulphydryl-mediated DNA breakage by phlemomycin in Escherichia coli.

Mutat. Res. 42 , 181-190, (1977)

Sulphydryl-mediated DNA breakage, which is induced by the antibiotic phleomycin in vitro, has been found to contribute significantly to the DNA damage produced by phleomycin in Escherichia coli. The e...

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