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地红霉素

地红霉素用途

Dirithromycin(LY 237216)是大环内酯类糖肽抗生素,能与细菌核糖体70S中的50S亚基相结合。

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地红霉素名称

[ CAS 号 ]:
62013-04-1

[ 中文名 ]:
地红霉素

[ 英文名 ]:
Dirithromycin

[中文别名 ]:

布大卡因

[英文别名 ]:

Noriclan
Dynabac
Dirythromycin
4,16-Dioxa-14-azabicyclo[11.3.1]heptadecan-5-one
MFCD00865041
ASE 136
Dirithomycin
Valodin
Dirithromycin
Antibiotic AS-E 136

地红霉素生物活性

[ 描述 ]:

Dirithromycin(LY 237216)是大环内酯类糖肽抗生素,能与细菌核糖体70S中的50S亚基相结合。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Brogden, R.N. and D.H. Peters, Dirithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy. Drugs, 1994. 48(4): p. 599-616.

[2]. Wintermeyer, S.M., S.M. Abdel-Rahman, and M.C. Nahata, Dirithromycin: a new macrolide. Ann Pharmacother, 1996. 30(10): p. 1141-9.

[3]. Sides, G.D., et al., Pharmacokinetics of dirithromycin. J Antimicrob Chemother, 1993. 31 Suppl C: p. 65-75.

[相关活性小分子]

地红霉素物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
871.8±65.0 °C at 760 mmHg

[ 熔点 ]:
185 - 189ºC

[ 分子式 ]:
C₄₂H₇₈N₂O₁₄

[ 分子量 ]:
835.074

[ 闪点 ]:
481.0±34.3 °C

[ 精确质量 ]:
834.545288

[ PSA ]:
196.33000

[ LogP ]:
2.84

[ 外观性状 ]:
晶体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.533

[ 储存条件 ]:
-20°C

地红霉素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R42/43

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
29419000

地红霉素制备

【方法一】
下列化合物和2-(2-甲氧基乙氧基)乙醛，在乙醇中于室温下搅拌24h；或者和2-(2-甲氧基乙氧基)乙醛的甲缩醛或乙缩醛，在二氧六环-水中，Dowex 50W存在下，在室温下搅拌6h，均可得到地红霉素。

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地红霉素海关

[ 海关编码 ]: 29419000

地红霉素文献

The new macrolide antibiotics: azithromycin, clarithromycin, dirithromycin, and roxithromycin.

Ann. Pharmacother. 26(1) , 46-55, (1992)

To review the chemistry, antimicrobial spectrum, pharmacokinetics, clinical trials, adverse effects, and drug interactions of four new macrolide antibiotics: azithromycin, clarithromycin, dirithromyci...

Pharmacokinetics of dirithromycin.

J. Antimicrob. Chemother. 31 Suppl C , 65-75, (1993)

Dirithromycin is a new member of the macrolide class of antibiotics and has been developed for oral administration. Dirithromycin is a 14-membered lactone ring macrolide and is the C9-oxazine derivati...

Modulation of human polymorphonuclear neutrophil function by macrolides: preliminary data concerning dirithromycin.

J. Antimicrob. Chemother. 31 Suppl C , 51-64, (1993)

Polymorphonuclear neutrophils (PMN) play a prominent role in the host response to infectious diseases. One major bactericidal mechanism used by these cells is the production of reactive oxygen species...

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