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Ciproxifan马来酸盐

Ciproxifan马来酸盐用途

Ciproxifan(FUB-359)马来酸盐是高活性的H3受体拮抗剂,IC50为9.2 nM,对其它亚型受体的亲和力较低。

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Ciproxifan马来酸盐名称

[ CAS 号 ]:
184025-19-2

[ 中文名 ]:
环丙基[4-[3-(1H-咪唑-4-基)丙氧基]苯基]甲酮马来酸盐

[ 英文名 ]:
Ciproxifan Maleate

[英文别名 ]:

FUB 359 maleate salt
Ciproxifan maleate
cc-128
Ciproxifan moleate
FUB359 maleate
Ciproxifan (maleate)

Ciproxifan马来酸盐生物活性

[ 描述 ]:

Ciproxifan(FUB-359)马来酸盐是高活性的H3受体拮抗剂,IC50为9.2 nM,对其它亚型受体的亲和力较低。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 神经疾病

[参考文献]

[1]. Motawaj M, Arrang JM. Ciproxifan, a histamine H?-receptor antagonist?/?inverse agonist, modulates methamphetamine-induced sensitization in mice. Eur J Neurosci. 2011 Apr;33(7):1197-204. doi: 10.1111/j.1460-9568.2011.07618.x.

[2]. Bardgett ME, Davis NN, Schultheis PJ, Griffith MS. Ciproxifan, an H3 receptor antagonist, alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease. Neurobiol Learn Mem. 2011 Jan;95(1):64-72.

[3]. Bardgett ME, Points M, Kleier J, Blankenship M, Griffith MS. The H3 antagonist, ciproxifan, alleviates the memory impairment but enhances the motor effects of MK-801 (dizocilpine) in rats. Neuropharmacology. 2010 Nov;59(6):492-502.

[4]. Day M, et al . Differential effects of ciproxifan and nicotine on impulsivity and attention measures in the 5-choice serial reaction time test. Biochem Pharmacol. 2007 Apr 15;73(8):1123-34.

[5]. Pillot C, Héron A, Schwartz JC, Arrang JM. Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, modulates the effects of methamphetamine on neuropeptide mRNA expression in rat striatum. Eur J Neurosci. 2003 Jan;17(2):307-14.

[相关活性小分子]

Ciproxifan马来酸盐物理化学性质

[ 沸点 ]:
743.6ºC at 760 mmHg

[ 分子式 ]:
C₂₀H₂₂N₂O₆

[ 分子量 ]:
386.398

[ 闪点 ]:
403.5ºC

[ 精确质量 ]:
386.147797

[ PSA ]:
129.58000

[ LogP ]:
2.72580

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
3.22E-23mmHg at 25°C

[ 储存条件 ]:
-20℃

Ciproxifan马来酸盐MSDS

详细MSDS(安全技术说明书)

Ciproxifan马来酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H317-H319-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

Ciproxifan马来酸盐文献

Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist.

J. Pharmacol. Exp. Ther. 287 , 658-666, (1998)

Ciproxifan, i.e., cyclopropyl-(4-(3-1H-imidazol-4-yl)propyloxy) phenyl) ketone, belongs to a novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a competitive antagonis...

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