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神经储钙蛋白基质

神经储钙蛋白基质用途

Calcineurin substrate是来自cAMP依赖性蛋白激酶调节性RII亚基的多肽。它可用于钙调神经磷酸酶活力的测定。

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神经储钙蛋白基质名称

[ CAS 号 ]:
113873-67-9

[ 中文名 ]:
钙调神经磷酸酶底物

[ 英文名 ]:
Calcineurin Substrate trifluoroacetate salt

[中文别名 ]:

[英文别名 ]:

MFCD00236901
DLDVPIPGRFDRRVSVAAE

神经储钙蛋白基质生物活性

[ 描述 ]:

Calcineurin substrate是来自cAMP依赖性蛋白激酶调节性RII亚基的多肽。它可用于钙调神经磷酸酶活力的测定。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

研究领域 >> 神经疾病

多肽产品

[体外研究]

钙调神经磷酸酶(PP2B)是一种由细胞钙控制的丝氨酸/苏氨酸磷酸酶,涉及多种生物反应,包括淋巴细胞活化,神经元和肌肉发育,神经突向外生长和脊椎动物心脏瓣膜的形态发生[1]。

[参考文献]

[1]. Crabtree GR, et al. Calcium, calcineurin, and the control of transcription. J Biol Chem. 2001 Jan 26;276(4):2313-6.

[相关活性小分子]

神经储钙蛋白基质物理化学性质

[ 分子式 ]:
C₉₂H₁₅₀N₂₈O₂₉

[ 分子量 ]:
2112.35000

[ 精确质量 ]:
2111.11000

[ PSA ]:
924.67000

[ LogP ]:
1.58550

[ 储存条件 ]:
−20°C

神经储钙蛋白基质MSDS

详细MSDS(安全技术说明书)

神经储钙蛋白基质安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

神经储钙蛋白基质文献

Endoplasmic reticulum vacuolation and unfolded protein response leading to paraptosis like cell death in cyclosporine A treated cancer cervix cells is mediated by cyclophilin B inhibition.

Biochim. Biophys. Acta 1843(11) , 2497-512, (2014)

Cyclosporine A (CsA), a widely used immunosuppressant shows cytotoxic effects by either inducing apoptosis or redirecting the cell towards non-apoptotic cell death. However, there still remains a lacu...

Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB.

Retrovirology 12 , 23, (2015)

The exact molecular mechanisms regarding HTLV-1 Tax-mediated viral gene expression and CD4 T-cell transformation have yet to be fully delineated. Herein, utilizing virus-infected primary CD4+ T cells ...

Nonradioactive assay for protein phosphatase 2B (calcineurin) activity using a partial sequence of the subunit of cAMP-dependent protein kinase as substrate.

Anal. Biochem. 216 , 147, (1994)

Currently, protein phosphatase 2B (calcineurin) activity is assayed based on release of [32P]phosphate from a 19-amino acid peptide (partial sequence of the regulatory subunit of cAMP-dependent protei...

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