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泼尼松龙法呢酯

泼尼松龙法呢酯用途

PNF21 是一种经皮激素,具有抗炎活性。
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泼尼松龙法呢酯名称

[ CAS 号 ]:
118244-44-3

[ 中文名 ]:
泼尼松龙法呢酯

[ 英文名 ]:
Prednisolone Farnesylate

[中文别名 ]:

[英文别名 ]:

泼尼松龙法呢酯生物活性

[ 描述 ]:

PNF21 是一种经皮激素,具有抗炎活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
研究领域 >> 炎症/免疫

[体外研究]

PNF21(泼尼松龙法尼醇,PNF-21)是一种合成的糖皮质激素,它是泼尼松龙及其酯法戊烯酸酯的化合物,已知可抑制佐剂诱导的关节炎的局部肿胀[1]。

[参考文献]

[1]. Kato N, et al. Treatment of the chronic inflammation in peripheral target tissue improves the crushed nerve recovery in the rat: histopathological assessment of the nerve recovery. J Neurol Sci. 2002 Oct 15;202(1-2):69-74.


[相关活性小分子]

磺丁基-β-环糊精钠盐 | 环孢霉素A | 2-(3,6-二乙酰氧基-2,7-二氯-9H-氧杂蒽-9-基)苯甲酸 | 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 | GW4869 | 乙莫克舍 | (2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-硫代双(4-(4-(3-氟苯基)-1H-1,-1H-1,2,3-三唑-1-基)-2-(羟甲基)四氢-2H-吡喃-3,5-二醇) | Mitoquinone甲磺酸盐 | GSK2795039 | CBIC2 | BAPTA-AM | AP20187 | GKT137831 | D-(-)-荧光素 | 单响尾蛇毒蛋白

泼尼松龙法呢酯物理化学性质

[ 密度 ]:
1.15g/cm3

[ 沸点 ]:
712.5ºC at 760mmHg

[ 分子式 ]:
C36H50O6

[ 分子量 ]:
578.77900

[ 闪点 ]:
217.5ºC

[ 精确质量 ]:
578.36100

[ PSA ]:
100.90000

[ LogP ]:
6.52770

[ 蒸汽压 ]:
1.88E-23mmHg at 25°C

[ 折射率 ]:
1.569

[ 储存条件 ]:
-20°C，密闭，干燥

泼尼松龙法呢酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU3832200
CHEMICAL NAME :
Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-((3,7,11-trimethyl-1-oxo-2,6,10- dodecatrienyl)-oxy)-, (11beta,21(2E,6E))-
CAS REGISTRY NUMBER :
118244-44-3
LAST UPDATED :
199306
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C36-H50-O6
MOLECULAR WEIGHT :
578.86

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1456 mg/kg/13W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl 3),49,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
728 mg/kg/52W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal Endocrine - changes in spleen weight Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl 3),91,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2730 mg/kg/13W-I
TOXIC EFFECTS :
Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Related to Chronic Data - death
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl 3),1,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
291 mg/kg/13W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl 3),123,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
291 mg/kg/52W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight Blood - changes in leukocyte (WBC) count Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl 3),161,1992 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
>11 mg/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Specific Developmental Abnormalities - hepatobiliary system
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl 3),217,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
3250 ug/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 17(Suppl 3),241,1992
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推荐生产厂家/供应商：

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥5619.0/1mg

联系人：夏言

产品详情：[Perfemiker]泼尼松龙法尼酯,98%

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