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氟氢可的松

氟氢可的松用途

Fludrocortisone是一种合成的盐皮质激素,具有抗炎功能。

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氟氢可的松名称

[ CAS 号 ]:
127-31-1

[ 中文名 ]:
氟氢可的松

[ 英文名 ]:
fludrocortisone

[英文别名 ]:

Fludrocortone
9a-Fluorocortisol
9α-Fluorocortisol
Alflorone
Fluorocortisone
9a-Fluorohydrocortisone
Fludrocortisona [INN-Spanish]
MFCD00083333
9-α-Fluoro-17-hydroxycorticosterone
Fluohydrocortisone

氟氢可的松生物活性

[ 描述 ]:

Fludrocortisone是一种合成的盐皮质激素,具有抗炎功能。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 盐皮质激素受体

研究领域 >> 炎症/免疫

[参考文献]

[1]. Jaal J, et al. Small Cell Lung Cancer Patient with Profound Hyponatremia and Acute Neurological Symptoms: An Effective Treatment with Fludrocortisone. Case Rep Oncol Med. 2015;2015:286029.

[2]. Mori T, et al. Improved efficiency of hypervolemic therapy with inhibition of natriuresis by fludrocortisone in patients with aneurysmal subarachnoid hemorrhage. Journal of Neurosurgery [1999, 91(6):947-952]

[相关活性小分子]

氟氢可的松物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
564.7±50.0 °C at 760 mmHg

[ 熔点 ]:
208-212ºC

[ 分子式 ]:
C₂₁H₂₉FO₅

[ 分子量 ]:
380.450

[ 闪点 ]:
295.3±30.1 °C

[ 精确质量 ]:
380.199890

[ PSA ]:
94.83000

[ LogP ]:
1.23

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±3.5 mmHg at 25°C

[ 折射率 ]:
1.584

[ 储存条件 ]:
Refrigerator

氟氢可的松毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5025000

CHEMICAL NAME :: Pregn-4-ene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-

CAS REGISTRY NUMBER :: 127-31-1

BEILSTEIN REFERENCE NO. :: 3014278

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C21-H29-F-O5

MOLECULAR WEIGHT :: 380.50

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A1 BF CQ E1 FV1Q FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 8750 ug/kg

SEX/DURATION :: female 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: JEMEAV Journal of Experimental Medicine. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1896- Volume(issue)/page/year: 102,347,1955

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 100 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: 28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th International Committee on Laboratory Animals, Hanover, 1972," Speigel, A. ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973 Volume(issue)/page/year: -,85,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 mg/kg

SEX/DURATION :: female 13-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: 28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th International Committee on Laboratory Animals, Hanover, 1972," Speigel, A. ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973 Volume(issue)/page/year: -,85,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 mg/kg

SEX/DURATION :: female 13-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: 28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th International Committee on Laboratory Animals, Hanover, 1972," Speigel, A. ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973 Volume(issue)/page/year: -,85,1973

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氟氢可的松安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
63

[ 安全声明 (欧洲) ]:
22-26-36

[ 海关编码 ]:
2937210000

氟氢可的松合成路线

详细合成路线

氟氢可的松上下游产品

氟氢可的松上游产品

氟氢可的松下游产品

氟氢可的松海关

[ 海关编码 ]: 2937210000