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盐酸哌立度酯

盐酸哌立度酯用途

Piperidolate盐酸盐是一种抗胆碱剂,作用于大鼠和狗,可抑制乙酰胆碱引起的肠抽筋。

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盐酸哌立度酯名称

[ CAS 号 ]:
129-77-1

[ 中文名 ]:
盐酸哌立度酯

[ 英文名 ]:
Piperidolate (hydrochloride)

[中文别名 ]:

地海哌酮

[英文别名 ]:

Edelel hydrochloride
Piperidolat-hydrochlorid
Crapinon
MFCD00057377
Piperidolate HCl
1-Ethyl-3-piperidyl diphenylacetate hydrochloride
EINECS 204-964-5
Piperidolate hydrochloride
Dactil
N-Ethyl-3-piperidyl diphenylacetate hydrochloride

盐酸哌立度酯生物活性

[ 描述 ]:

Piperidolate盐酸盐是一种抗胆碱剂,作用于大鼠和狗,可抑制乙酰胆碱引起的肠抽筋。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

信号通路 >> 神经信号通路 >> mAChR

研究领域 >> 神经疾病

[相关活性小分子]

盐酸哌立度酯物理化学性质

[ 沸点 ]:
431.9ºC at 760mmHg

[ 分子式 ]:
C₂₁H₂₆ClNO₂

[ 分子量 ]:
359.89000

[ 闪点 ]:
136ºC

[ 精确质量 ]:
359.16500

[ PSA ]:
29.54000

[ LogP ]:
4.58590

[ 蒸汽压 ]:
1.16E-07mmHg at 25°C

[ 储存条件 ]:
2-8℃

盐酸哌立度酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH2975000

CHEMICAL NAME :: Acetic acid, diphenyl-, 1-ethyl-3-piperidyl ester, hydrochloride

CAS REGISTRY NUMBER :: 129-77-1

LAST UPDATED :: 199603

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C21-H25-N-O2.Cl-H

MOLECULAR WEIGHT :: 359.93

WISWESSER LINE NOTATION :: T6NTJ A2 COVYR&R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,97,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1040 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 26 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 104,269,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,97,1969

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盐酸哌立度酯安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933399090

盐酸哌立度酯制备

生产方法简介

由乙炔和异丁醇在碱催化下加成制得。

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盐酸哌立度酯海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

盐酸哌立度酯

盐酸哌立度酯用途

盐酸哌立度酯名称

盐酸哌立度酯生物活性

盐酸哌立度酯物理化学性质

盐酸哌立度酯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

盐酸哌立度酯安全信息

盐酸哌立度酯制备

盐酸哌立度酯海关

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