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盐酸西维美林

盐酸西维美林用途

Cevimeline盐酸半水合物是毒蕈碱型受体激动剂。

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盐酸西维美林名称

[ CAS 号 ]:
153504-70-2

[ 中文名 ]:
盐酸西维美林

[ 英文名 ]:
Cevimeline hydrochloride hemihydrate

[中文别名 ]:

西维美林盐酸盐半水合物

[英文别名 ]:

Unii-p81Q6V85np
cevimeline hydrochloride
CeviMeline hydrochloride heMihydrates
Cevimeline hydrochloride hemihydrate
Cevimeline HCl 1/2H2o
CevimelineHCl
Cevimeline (hydrochloride hemihydrate)

盐酸西维美林生物活性

[ 描述 ]:

Cevimeline盐酸半水合物是毒蕈碱型受体激动剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

信号通路 >> 神经信号通路 >> mAChR

研究领域 >> 神经疾病

[参考文献]

[1]. Iga Y, Arisawa H, Ogane N, Saito Y, Tomizuka T, Nakagawa-Yagi Y, Masunaga H, Yasuda H, Miyata N. (+/-)-cis-2-methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride, hemihydrate (SNI-2011, cevimeline hydrochloride) induces saliva and tear secretions

[2]. Omori Y, Asari T, Maruyama K, Kusama H, Kojima M, Shibata N. Effects of pilocarpine hydrochloride and cevimeline on submandibular/sublingual salivation in rat xerostomia model produced by X-ray irradiation. Arzneimittelforschung. 2003;53(5):342-50.

[3]. Washio, Takuo; Kohsaka, Kazuhiro; Arisawa, Hirohiko; et al.Pharmacokinetics and metabolism of radiolabeled SNI-2011, a novel muscarinic receptor agonist, in healthy volunteers: Comprehensive understanding of absorption, metabolism and excretion using radi

[4]. Washio, Takuo; Kohsaka, Kazuhiro; Arisawa, Hirohiko; et al.Pharmacokinetics and metabolism of the novel muscarinic receptor agonist SNI-2011 in rats and dogs.Arzneimittel-Forschung (2003), 53(1), 26-33.

[5]. Arisawa, Hirohiko; Fukui, Kenji; Imai, Eiichi; et al.General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjogren's syndrome. Arzneimittel-Forschung (2002), 52(4), 225-232.

[相关活性小分子]

盐酸西维美林物理化学性质

[ 密度 ]:
1.19g/cm3

[ 沸点 ]:
308.5ºC at 760mmHg

[ 分子式 ]:
C₂₀H₃₅ClN₂O₂S₂

[ 分子量 ]:
435.09

[ 闪点 ]:
140.4ºC

[ PSA ]:
84.77000

[ LogP ]:
4.53590

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.000676mmHg at 25°C

[ 储存条件 ]:
-20°C

盐酸西维美林MSDS

盐酸西维美林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WG9634812

CAS REGISTRY NUMBER :: 153504-70-2

LAST UPDATED :: 199703

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H17-N-O-S.Cl-H.1/2H2-O

MOLECULAR WEIGHT :: 244.78

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 139 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5340821

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5340821

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5340821

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盐酸西维美林安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

盐酸西维美林合成路线

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盐酸西维美林文献

Effects of pilocarpine and cevimeline on Ca2+ mobilization in rat parotid acini and ducts.

J. Med. Invest. 56 Suppl , 375, (2009)

Previous reports suggested that there is no significant difference in the binding affinity of pilocarpine and cevimeline on muscarinic receptors (1). However, in vivo studies from our laboratory sugge...

Cevimeline enhances the excitability of rat superior salivatory neurons.

J. Med. Invest. 56 Suppl , 267-9, (2009)

Cevimeline, a therapeutic drug for xerostomia, is an agonist of muscarinic acetylcholine receptors (mAChRs), and directly stimulates the peripheral mAChRs of the salivary glands. Since cevimeline is d...

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