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2-苯基-4-喹啉羧酸

2-苯基-4-喹啉羧酸用途

Cinchophen有效治疗犬类慢性消化性溃疡。

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2-苯基-4-喹啉羧酸名称

[ CAS 号 ]:
132-60-5

[ 中文名 ]:
2-苯基-4-喹啉羧酸

[ 英文名 ]:
Cinchophen

[中文别名 ]:

[英文别名 ]:

4-Quinolinecarboxylic acid, 2-phenyl-
MFCD00006750
2-Phenyl-4-quinolinecarboxylic acid
CINCHOPHEN
2-Phenylcinchoninic Acid
2-phenylquinoline-4-carboxylic acid
EINECS 205-067-1

2-苯基-4-喹啉羧酸生物活性

[ 描述 ]:

Cinchophen有效治疗犬类慢性消化性溃疡。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[相关活性小分子]

2-苯基-4-喹啉羧酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
456.9±33.0 °C at 760 mmHg

[ 熔点 ]:
213-216ºC

[ 分子式 ]:
C₁₆H₁₁NO₂

[ 分子量 ]:
249.264

[ 闪点 ]:
230.1±25.4 °C

[ 精确质量 ]:
249.078979

[ PSA ]:
50.19000

[ LogP ]:
3.99

[ 外观性状 ]:
固体;White to Light yellow to Green powder to crystal

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.682

[ 储存条件 ]:
Store below +30°C.

[ 水溶解性 ]:
alcohol: soluble1g in 120ml(lit.) | Insoluble in water

2-苯基-4-喹啉羧酸MSDS

详细MSDS(安全技术说明书)

2-苯基-4-喹啉羧酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD4025000

CHEMICAL NAME :: Cinchoninic acid, 2-phenyl-

CAS REGISTRY NUMBER :: 132-60-5

BEILSTEIN REFERENCE NO. :: 0192803

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C16-H11-N-O2

MOLECULAR WEIGHT :: 249.28

WISWESSER LINE NOTATION :: T66 BNJ CR& EVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 214 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,177,1969

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 74 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,260,1947

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: LDTU** "Narkoseversuche mit Hoheren Alkoholen und Stickstoffderivaten, Dissertation," Leube, F., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1931 Volume(issue)/page/year: -,-,1931

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 116,154,1958

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 74,365,1942 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2800 mg/kg/7D-I

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 48,341,1933

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2-苯基-4-喹啉羧酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
UN 3249

[ WGK德国 ]:
3

[ RTECS号 ]:
GD4025000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2933499090

2-苯基-4-喹啉羧酸合成路线

详细合成路线

2-苯基-4-喹啉羧酸制备

生产方法简述

靛红配制成钠盐，经开环生成邻氨基苯甲酰甲酸钠，再与苯乙酮进行环合，得到辛可芬钠，用乙酸或盐酸酸化即得辛可芬

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2-苯基-4-喹啉羧酸海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-苯基-4-喹啉羧酸文献

Improved sample treatment for the determination of 17 strong sorbed quinolone antibiotics from compost by ultra high performance liquid chromatography tandem mass spectrometry.

Talanta 138 , 247-57, (2015)

The use of compost from sewage sludge for agricultural application is nowadays increasing, since composting is recognized as one of the most important recycling options for this material, being a sour...

Cyclometalated iridium(III) bipyridyl-phenylenediamine complexes with multicolor phosphorescence: synthesis, electrochemistry, photophysics, and intracellular nitric oxide sensing.

ChemMedChem 9(6) , 1316-29, (2014)

We present a new class of phosphorescent cyclometalated iridium(III) bipyridyl-phenylenediamine complexes [Ir(N^C)2 (bpy-DA)](PF6 ) (bpy-DA=4-(N-(2-amino-5-methoxyphenyl)aminomethyl)-4'-methyl-2,2'-bi...

Monitoring Antibiotic Use and Residue in Freshwater Aquaculture for Domestic Use in Vietnam.

Ecohealth 12 , 480-9, (2015)

Vietnam is an important producer of aquaculture products, and aquatic products are essential to the Vietnamese diet. However, Vietnam also has very little enforced regulation pertaining to antibiotic ...

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2-苯基-4-喹啉羧酸

2-苯基-4-喹啉羧酸用途

2-苯基-4-喹啉羧酸名称

2-苯基-4-喹啉羧酸生物活性

2-苯基-4-喹啉羧酸物理化学性质

2-苯基-4-喹啉羧酸MSDS

详细MSDS(安全技术说明书)

2-苯基-4-喹啉羧酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

2-苯基-4-喹啉羧酸安全信息

2-苯基-4-喹啉羧酸合成路线

详细合成路线

2-苯基-4-喹啉羧酸制备

2-苯基-4-喹啉羧酸海关

2-苯基-4-喹啉羧酸文献

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