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CP-96345

CP-96345用途

CP-96345是一种特异、高效、口服活性的速激肽和P物质受体非肽抑制剂。CP-96345可防止P物质和神经激肽A引起的血压下降。CP-96345可用于研究神经源性炎症[1]。

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CP-96345名称

[ CAS 号 ]:
132746-60-2

[ 英文名 ]:
CP-96345

[英文别名 ]:

CP 96,345

CP-96345生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 神经信号通路 >> 神经激肽受体

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体

[ 靶点 ]

Tachykinin, Substance P receptor[1]

[参考文献]

[1]. Lembeck F, et al. The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation. Br J Pharmacol. 1992;105(3):527-530.

CP-96345物理化学性质

[ 密度 ]:
1.15g/cm3

[ 沸点 ]:
541.5ºC at 760 mmHg

[ 分子式 ]:
C₂₈H₃₂N₂O

[ 分子量 ]:
412.57

[ 闪点 ]:
281.3ºC

[ 精确质量 ]:
412.25100

[ PSA ]:
24.50000

[ LogP ]:
5.40850

[ 蒸汽压 ]:
8.65E-12mmHg at 25°C

[ 折射率 ]:
1.633

[ 储存条件 ]:
-20°C

CP-96345安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335-H400

[ 警示性声明 ]:
P261-P273-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

CP-96345文献

Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice.

Br. J. Pharmacol. 172(3) , 924-39, (2015)

Spinal voltage-gated calcium channels (VGCCs) are pivotal regulators of painful and inflammatory alterations, representing attractive therapeutic targets. We examined the effects of epidural administr...

Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure.

Am. J. Physiol. Lung Cell. Mol. Physiol. 294(5) , L912-20, (2008)

This study aimed to 1) assess whether substance P (SP) acts via neurokinin (NK)-1 and NK-2 receptors to stimulate neurogenic inflammation (indicated by formation of ICAM-1 expression and oxidative str...

An in vitro model of morphine withdrawal manifests the enhancing effect on human immunodeficiency virus infection of human T lymphocytes through the induction of substance P.

Am. J. Pathol. 169(5) , 1663-70, (2006)

Opioid withdrawal is a crucial and recurring event during the course of opioid abuse that has a negative impact on the immune system. In this study, we investigated whether abrupt withdrawal (AW) or p...

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