Ethacrynic acid D5

Ethacrynic acid D5用途

Ethacrynic acid D5 是 Ethacrynic acid 的氘代物。Ethacrynic acid 是一种利尿剂。Ethacrynic acid 是谷胱甘肽 S-转移酶 (GSTs) 的抑制剂。Ethacrynic acid 是 NF-κB 信号传导途径的有效抑制剂,并且还调节白三烯的形成。Ethacrynic acid 还抑制 L 型电压依赖性和储存操作的钙通道,从而导致气道平滑肌细胞松弛。Ethacrynic acid 具有抗炎特性,可减轻类维生素A诱导的小鼠耳部水肿。

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Ethacrynic acid D5名称

[ CAS 号 ]:
1330052-59-9

[ 英文名 ]:
Ethacrynic acid D5

[英文别名 ]:

Ethacrynic acid D5生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

信号通路 >> 代谢酶/蛋白酶 >> 谷胱甘肽S-转移酶

研究领域 >> 炎症/免疫

[ 靶点 ]

Glutathione S-transferases (GSTs)[1]; NF-κB-signaling pathway[2]; L-type voltage-dependent and store-operated calcium channel[3]

[参考文献]

[1]. Li XQ, et al. Metabolism of Strained Rings: Glutathione S-transferase-Catalyzed Formation of a Glutathione-Conjugated Spiro-azetidine without Prior Bioactivation. Drug Metab Dispos. 2019 Nov;47(11):1247-1256.

[2]. Harada T, et al. Ethacrynic acid decreases expression of proinflammatory intestinal wall cytokines and ameliorates gastrointestinal stasis in murine postoperative ileus. Clinics (Sao Paulo). 2018 Oct 18;73:e332.

[3]. Zhao XX, et al. Ethacrynic acid inhibits airway smooth muscle contraction in mice. Sheng Li Xue Bao. 2019 Dec 25;71(6):863-873.

[4]. Byun HJ, et al. Ethacrynic Acid Inhibits Sphingosylphosphorylcholine-Induced Keratin 8 Phosphorylation and Reorganization via Transglutaminase-2 Inhibition. Biomol Ther (Seoul). 2013 Sep 30;21(5):338-42.

Ethacrynic acid D5物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
480.0±45.0 °C at 760 mmHg

[ 分子式 ]:
C₁₃H₇D₅Cl₂O₄

[ 分子量 ]:
308.169

[ 闪点 ]:
244.1±28.7 °C

[ 精确质量 ]:
307.042633

[ LogP ]:
3.36

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.559

[ 储存条件 ]:
-20°C，干燥，密封

Ethacrynic acid D5安全信息

[ 危害码 (欧洲) ]:
Xi